Crystal structures of all-alpha type membrane proteins

McLuskey, K., Roszak, A. W., Zhu, Y. S. and Isaacs, N. W. (2010) Crystal structures of all-alpha type membrane proteins. European Biophysics Journal with Biophysics Letters, 39(5), pp. 723-755. (doi: 10.1007/s00249-009-0546-6)

Abstract

Integral membrane proteins are involved in a wide range of essential biological functions and the determination of their three-dimensional structures plays a central role in understanding their function. This review focuses on the structures of one class of integral membrane proteins: the functionally diverse all-alpha type membrane proteins. It gives an overview of all the structures determined by X-ray crystallography, describing each system and structure in turn. It shows that the structures of all-alpha type membrane proteins have made valuable contributions to understanding structure-function relationships in membrane proteins. These range from the first insights into the function of exciting individual proteins to an in-depth knowledge of protein function from entire biological systems.

• Item Type: Articles
• Keywords: ABC TRANSPORTER ARCHITECTURE All-alpha type membrane proteins BACTERIAL REACTION-CENTER CRYSTAL Crystal structures CRYSTAL-STRUCTURE CRYSTAL-STRUCTURES CYTOCHROME BC(1) COMPLEX FAMILY INTRAMEMBRANE PROTEASE LIGHT-HARVESTING COMPLEX MITOCHONDRIAL ADP/ATP CARRIER PHOTOSYNTHETIC REACTION-CENTER PROTEINS PROTON-TRANSFER PATHWAYS SENSORY RHODOPSIN-II SYSTEMS X-Ray Crystallography X-RAY-STRUCTURE
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Roszak, Dr Aleksander and McLuskey, Dr Karen and Isaacs, Professor Neil and Zhu, Dr Yanshi
• Authors: McLuskey, K., Roszak, A. W., Zhu, Y. S., and Isaacs, N. W.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: European Biophysics Journal with Biophysics Letters
• ISSN: 0175-7571