Iaroshenko, V. O., Groth, U., Kryvokhyzha, N. V., Obeid, S., Tolmachev, A. A. and Wesch, T. (2008) A practical synthetic route to benzofuro[2,3-b]pyridine and trifluoromethyl-alpha-carbolines. Synlett(3), pp. 343-346. (doi: 10.1055/s-2008-1032042)
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Abstract
In situ generated benzofuran-2-amine reacts with 1,3-CCC-diclectrophiles, such as CF3-containing beta-diketones, 3-formylchromone, methyl-2,4-dioxopentanoate and pentafluorobenzaldehyde, and the reaction leads to the formation of benzofuro[2,3-b]pyridine ring system. By using a similar approach 4-trifluoromethyl-alpha-carbolines were synthesized starting from indole-2-amine.
| Item Type: | Articles |
|---|---|
| Keywords: | 1-AZA-9-OXAFLUORENES ACIDS annulation CONVERSION DERIVATE electrophilic aromatic substitution FACILE SYNTHESIS FLT3 furanamine IN-SITU indoleamine INHIBITORS INTEGRASE LEUKEMIA Pyridine RING ROUTE SYSTEM |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | Iaroshenko, V. O., Groth, U., Kryvokhyzha, N. V., Obeid, S., Tolmachev, A. A., and Wesch, T. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Synlett |
| ISSN: | 0936-5214 |
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