Baker, T. M., Edmonds, D.J., Hamilton, D., O'Brien, C.J. and Procter, D. J. (2008) Synthesis and reactions of the pestalotiopsin skeleton. Angewandte Chemie (International Edition), 47(30), pp. 5631-5633. (doi: 10.1002/anie.200801900)
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Abstract
Family ties: The pestalotiopsin framework has been constructed by using a SmI2-mediated cyclization and a Nozaki–Hiyama–Kishi coupling to construct the four- and nine-membered rings of the target, respectively. The first synthetic entry into the previously unexplored taedolidol family of natural products has been achieved through a stereoselective, acid-mediated cyclization of the pestalotiopsin skeleton.
| Item Type: | Articles |
|---|---|
| Keywords: | CHLORIDE FUNCTIONALIZED CYCLOBUTANOLS IODIDE natural products ORGANIC-SYNTHESIS pestalotiopsins REAGENTS REDUCTIONS samarium SAMARIUM(II)-MEDIATED 4-EXO-TRIG CYCLIZATION STEREOCONTROLLED APPROACH taedolidols TAXUS-BREVIFOLIA total synthesis UNSATURATED ALDEHYDES. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | Baker, T. M., Edmonds, D.J., Hamilton, D., O'Brien, C.J., and Procter, D. J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Angewandte Chemie (International Edition) |
| Journal Abbr.: | Angew Chem Int Ed Engl |
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
| ISSN: | 1433-7851 |
| ISSN (Online): | 1521-3773 |
| Published Online: | 23 June 2008 |
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