Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations

Patel, J.V. et al. (2010) Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations. Atherosclerosis, 209(2), pp. 579-584. (doi: 10.1016/j.atherosclerosis.2009.10.010)

Abstract

<b>Introduction</b>: Coronary heart disease (CHD) is exceptionally prevalent amongst globally dispersed migrant groups originating from the Indian subcontinent, but the contribution of dyslipidaemia to their increased risk remains poorly defined. <b>Methods</b>: Fasting lipids and lipoproteins, apolipoproteins (Apo), low density lipoprotein (LDL) diameter and oxidised LDL were measured amongst rural Indians in India (n = 294) and their migrant contemporaries in the UK (n = 242). The performance of qualitative and quantitative measures of lipid metabolism were compared in the discrimination of WHO defined metabolic risk and raised Framingham CHD risk scores (>15%) using Receiver Operating Characteristic (ROC) curves. <b>Results</b>: LDL diameter was correlated with triglycerides (R2 = 0.12, P < 0.001) and with high density lipoprotein (HDL) cholesterol levels (R2 = 0.15, P < 0.001) in both groups. Migrants had less small dense LDL (95% CI: 12.5–14.2%) vs. rural Indians (15.7–17.2, P < 0.05). On ROC analysis, triglycerides were the only consistent discriminators of metabolic and CHD risk scores (all P ≤ 0.001). Apo B was also a strong indicator of raised CHD risk scores. Irrespective of site, individuals with raised triglycerides also had higher total cholesterol and Apo B, denser LDL, lower HDL and more oxidised LDL (all P ≤ 0.01). <b>Discussion</b>: Fasting triglycerides reflect both qualitative and quantitative aspects of lipid metabolism, and are a comprehensive discriminator of CHD risk in this South Asian population.

• Item Type: Articles
• Keywords: APOLIPOPROTEIN-A-I Apolipoproteins ATHEROSCLEROSIS CARDIOVASCULAR-DISEASE CARE CHOLESTEROL Coronary heart disease CORONARY-HEART-DISEASE diabetes DIAMETER Discrimination DISEASE ENGLAND Epidemiology ETHNIC-GROUPS FRAMINGHAM GLOBAL BURDEN GLUCOSE-TOLERANCE HDL cholesterol HEART heart disease HEART-DISEASE INCREASED RISK INDICATOR INDIVIDUALS INSULIN-RESISTANCE LDL LEVEL LOW-DENSITY-LIPOPROTEIN Metabolism MYOCARDIAL-INFARCTION Oxidised LDL PERFORMANCE POPULATION PREVENTION RISK rural SCORE Small dense LDL South Asians SUBFRACTIONS
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Caslake, Professor Muriel
• Authors: Patel, J.V., Caslake, M.J., Vyas, A., Cruickshank, J.K., Prabhakaran, D., Bhatnagar, D., Reddy, K.S., Lip, G.Y.H., Mackness, M.I., Hughes, E.A., and Durrington, P.N.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences
• Journal Name: Atherosclerosis
• Publisher: Elsevier Ireland Ltd
• ISSN: 0021-9150
• ISSN (Online): 1879-1484
• Published Online: 13 October 2009