Lee, D. and Shaddick, G. (2007) Time-varying coefficient models for the analysis of air pollution and health outcome data. Biometrics, 63(4), pp. 1253-1261. (doi: 10.1111/j.1541-0420.2007.00776.x)
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Abstract
In this article a time-varying coefficient model is developed to examine the relationship between adverse health and short-term (acute) exposure to air pollution. This model allows the relative risk to evolve over time, which may be due to an interaction with temperature, or from a change in the composition of pollutants, such as particulate matter, over time. The model produces a smooth estimate of these time-varying effects, which are not constrained to follow a fixed parametric form set by the investigator. Instead, the shape is estimated from the data using penalized natural cubic splines. Poisson regression models, using both quasi-likelihood and Bayesian techniques, are developed, with estimation performed using an iteratively re-weighted least squares procedure and Markov chain Monte Carlo simulation, respectively. The efficacy of the methods to estimate different types of time-varying effects are assessed via a simulation study, and the models are then applied to data from four cities that were part of the National Morbidity, Mortality, and Air Pollution Study.
Item Type: | Articles |
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Additional Information: | The definitive version is available at www3.interscience.wiley.com |
Keywords: | Air pollution, Bayesian hierarchical models, epidemiology, penalized splines, time-varying coefficient models |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lee, Professor Duncan |
Authors: | Lee, D., and Shaddick, G. |
Subjects: | G Geography. Anthropology. Recreation > GE Environmental Sciences H Social Sciences > HA Statistics |
College/School: | College of Science and Engineering > School of Mathematics and Statistics > Statistics |
Journal Name: | Biometrics |
Publisher: | Wiley-Blackwell |
ISSN: | 0006-341X |
ISSN (Online): | 1541-0420 |
Published Online: | 09 April 2007 |
Copyright Holders: | Copyright © 2007 Wiley-Blackwell |
First Published: | First published in Biometrics 63(4):1253-1261 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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