Nweneka, C. V., Doherty, C. P., Cox, S. and Prentice, A. (2010) Iron delocalisation in the pathogenesis of malarial anaemia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104(3), pp. 175-184. (doi: 10.1016/j.trstmh.2009.08.007)
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Abstract
There is consensus that the pathophysiology of malaria-associated anaemia is multifactorial, but the precise mechanisms behind many of the haematological changes during malaria remain unclear. In this review, we attempt to build a composite picture of the pathophysiology of malarial anaemia using evidence from experimental, human and animal studies. We propose that cytokine- and hepcidin-mediated iron delocalisation, a principal mechanism in the anaemia of inflammation, plays an important role in the aetiology of malarial anaemia, and can explain some of the clinical and laboratory findings. These mechanisms interact with other aetiological determinants, such as dietary iron and micronutrient supply, helminth load, other infections and genetic variation, in determining the severity and associated features of anaemia. We suggest that iron delocalisation as a mechanism for malarial anaemia could be exploited for the development of alternative therapeutic strategies for post-malaria anaemia. Crown Copyright (C) 2009 Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved
| Item Type: | Articles |
|---|---|
| Keywords: | Anaemia BLOOD BLOOD-STAGE MALARIA CANCER CHRONIC DISEASE COOMBS ANTIGLOBULIN REACTIONS COPPER-DEFICIENT SWINE Ferroportin HEALTH Hepcidin Human INFECTION inflammation Iron Macrophage malaria MECHANISM MIGRATION INHIBITORY FACTOR NITRIC-OXIDE PLACEBO-CONTROLLED TRIAL PLASMODIUM-FALCIPARUM MALARIA RETICULOENDOTHELIAL SYSTEM TUMOR-NECROSIS-FACTOR |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Doherty, Dr Conor |
| Authors: | Nweneka, C. V., Doherty, C. P., Cox, S., and Prentice, A. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| ISSN: | 0035-9203 |
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