Ntali, G., Koutsari, C., Karakike, K., Makras, P., Skopouli, F., Mc Milan, M., Slater, C., Higgins, S., Zampelas, A. and Malkova, D. (2010) Erythrocyte fatty acid composition and insulin sensitivity in daughters of Type 2 diabetic patients and women with no family history of diabetes. Journal of Endocrinological Investigation, 33(5), pp. 306-312. (doi: 10.3275/6721)
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Abstract
Background: There is evidence that the impact of environmental factors on insulin sensitivity is modified by the presence of family history of diabetes. Aim: To compare the association between the erythrocyte phospholipid fatty acid composition (a biomarker of dietary fatty acids) and insulin sensitivity in daughters of Type 2 diabetic patients with the corresponding association in women without family history of diabetes. Material/subjects and methods: Eighteen offspring of Type 2 diabetic patients [age 30 +/- 6.5 yr; body mass index (BMI) 22.2 +/- 2.5 kg/m(2); body fat 31.8 +/- 5.1%] and 18 matched women (age 30.1 +/- 6.8 yr; BMI 22.2 +/- 1.8 kg/m(2); body fat 32.2 +/- 6.0%) participated in the study. Results: Insulin Sensitivity Index (ISI)-Matsuda tended to be lower (p=0.06) in the Offspring than the control group. Weight proportions of erythrocyte phospholipid saturated (SFA), polyunsaturated (PUFA), and monounsaturated fatty acids (MUFA) were similar between the two groups. In the offspring, erythrocyte total SFA were negatively correlated with ISI-Matsuda [r=-0.47, p<0.05), ISI(gly)-Belfiore (r=-0.52, p<0.05) and ISI(ffa)-Belfiore (r=-0.53, p<0.05)], whereas total PUFA were positively correlated with insulin sensitivity [ISI-Matsuda, r=0.46, p<0.05; ISI(gly)-Belfiore, r=0.53, p<0.05; ISI(ffa)-Belfiore, r=0.54, p<0.05]. No significant correlations were observed in the control group. Conclusions: The associations between erythrocyte fatty acid composition and insulin sensitivity are distinct between daughters of Type 2 diabetic patients and women without family history of diabetes. (J. Endocrinol. Invest. 33: 306-312, 2010) (C) 2010, Editrice Kurtis
| Item Type: | Articles |
|---|---|
| Keywords: | AGE ASSOCIATION ASSOCIATIONS BLOOD BMI body fat body mass index BODY-FAT BODY-MASS-INDEX CARE diabetes DIETARY-FAT DISTINCT ENVIRONMENTAL-FACTORS erythrocyte Erythrocytes FAMILY family history of Type 2 diabetes FAT fatty acids FATTY-ACIDS GENOME-WIDE ASSOCIATION GLUCOSE-TOLERANCE IMPACT INDEX insulin insulin sensitivity MASS MEN METABOLIC SYNDROME Metabolism monounsaturated PARENTS PATIENT patients phospholipids polyunsaturated RESISTANCE saturated SATURATED FAT SENSITIVITY INDEX SKELETAL-MUSCLE PHOSPHOLIPIDS TYPE-2 UNIT weight WOMEN |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Malkova, Dr Dalia and Slater, Dr Christine |
| Authors: | Ntali, G., Koutsari, C., Karakike, K., Makras, P., Skopouli, F., Mc Milan, M., Slater, C., Higgins, S., Zampelas, A., and Malkova, D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities |
| Journal Name: | Journal of Endocrinological Investigation |
| ISSN: | 0391-4097 |
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