Moug, S.J., Smith, D., Leen, E., Roxburgh, C. and Horgan, P.G. (2010) Evidence for a synchronous operative approach in the treatment of colorectal cancer with hepatic metastases: a case matched study. European Journal of Surgical Oncology, 36(4), pp. 365-370. (doi: 10.1016/j.ejso.2009.11.007)
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Abstract
Background: Traditionally, a staged operative approach has been used for patients with synchronous colorectal cancer and liver metastases in the U.K. With improved outcomes from hepatic resection the role of a synchronous operative approach needs re-evaluated. Methods: 32 consecutive patients with colorectal cancer and hepatic metastases that underwent a synchronous operative approach were individually case matched (according to: age; sex; ASA grade; type of hepatic and colonic resection) with patients that had undergone a staged approach. The following variables were analysed: operative blood loss; in hospital morbidity and mortality; duration of hospital stay; disease free and overall survival. Results: Operative blood losses were: synchronous group, median 475 mL (range 150-850 mL) vs median 425 mL (range 50-1700 mL), (p > 0.050). There were no significant differences in morbidity: (34% synchronous group vs 59%, p = 0.690) with no recorded mortality. Synchronous group had a shorter hospital stay (median 12 days [range 8-21] vs 20 [range 7-51], p = 0.008). There were no statistical differences between synchronous and staged patients for disease free and overall survival: 10 months (95% CI 5.8-13.7) versus 14 (95% CI 12.2-16.3; p =0.487) and 21% versus 24% at 5 years (p = 0.838). Conclusion: This present study provides supporting evidence for synchronous operative procedures in patients with colorectal liver metastases. Crown Copyright (c) 2009 Published by Elsevier Ltd. All rights reserved
| Item Type: | Articles |
|---|---|
| Keywords: | AGE BLOOD BLOOD-LOSS CANCER CENTRAL VENOUS-PRESSURE CHEMOTHERAPY Colorectal cancer DISEASE DURATION ENGLAND Hepatic metastases HEPATIC RESECTION INTRAOPERATIVE ULTRASONOGRAPHY LIVER METASTASES MORBIDITY MORTALITY outcome OUTCOMES PARTIAL-HEPATECTOMY PATIENT patients Radiofrequency ablation RESECTION Scotland sex SURGERY SURVIVAL Synchronous resections TRANSFUSION Treatment VARIABLES |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Horgan, Professor Paul and Roxburgh, Professor Campbell |
| Authors: | Moug, S.J., Smith, D., Leen, E., Roxburgh, C., and Horgan, P.G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities |
| Journal Name: | European Journal of Surgical Oncology |
| Publisher: | Elsevier |
| ISSN: | 0748-7983 |
| Published Online: | 19 January 2010 |
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