Marioni, R. E. et al. (2010) Association Between Raised Inflammatory Markers and Cognitive Decline in Elderly People With Type 2 Diabetes The Edinburgh Type 2 Diabetes Study. Diabetes, 59(3), pp. 710-713. (doi: 10.2337/db09-1163)
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Abstract
OBJECTIVE-To determine whether circulating levels of the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha are associated with cognitive ability and estimated lifetime cognitive decline in an elderly population with type 2 diabetes. RESEARCH DESIGN AND METHODS-A cross-sectional study of 1,066 men and women aged 60-75 years with type 2 diabetes and living in Lothian, Scotland (the Edinburgh Type 2 Diabetes Study), was performed. Seven cognitive tests were used to measure abilities in memory, nonverbal reasoning, information processing speed, executive function, and mental flexibility. The results were used to derive a general intelligence factor (g). A vocabulary-based test was administered as an estimate of peak prior cognitive ability. Results on the cognitive tests were assessed for statistical association with inflammatory markers measured in a venous blood sample at the time of cognitive testing. RESULTS-Higher IL-6 and TNF-alpha levels were associated with poorer age- and sex-adjusted scores on the majority of the individual cognitive tests. They were also associated with g using standardized regression coefficients -0.074 to -0.173 (P < 0.05). After adjusting for vocabulary, education level, cardiovascular dysfunction, duration of diabetes, and glycemic control, R,6 remained associated with three of the cognitive tests and with g. CONCLUSIONS-In this representative population of people with type 2 diabetes, elevated circulating levels of inflammatory markers were associated with poorer cognitive ability. IL-6 levels were also associated with estimated lifetime cognitive decline. Diabetes 59:710-713, 2010
| Item Type: | Articles |
|---|---|
| Keywords: | ADULTS AGE aged ARTERY ASSOCIATION BLOOD C-REACTIVE PROTEIN COGNITIVE DECLINE Cohort DESIGN diabetes DYSFUNCTION elderly EXECUTIVE FUNCTION GLYCEMIC CONTROL Impairment INDEX LEVEL MARKERS MEMORY MEN Mental PEOPLE POPULATION PROTEIN SCORE Scotland TUMOR-NECROSIS-FACTOR TYPE-2 WOMEN |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Rumley, Dr Ann and Lowe, Professor Gordon |
| Authors: | Marioni, R. E., Strachan, M. W. J., Reynolds, R. M., Lowe, G. D. O., Mitchell, R. J., Fowkes, F. G. R., Frier, B. M., Lee, A. J., Butcher, I., Rumley, A., Murray, G. D., Deary, I. J., and Price, J. F. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Diabetes |
| ISSN: | 0012-1797 |
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