Liew, F. Y., Pitman, N. I. and McInnes, I. B. (2010) Disease-associated functions of IL-33: the new kid in the IL-1 family. Nature Reviews Immunology, 10(2), pp. 103-110. (doi: 10.1038/nri2692) (PMID:20081870)
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Abstract
Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (T<sub>H</sub>2) cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting T<sub>H</sub>2-type immune responses. However, IL-33 can also promote the pathogenesis of asthma by expanding T<sub>H</sub>2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation. Thus IL-33 could be a new target for therapeutic intervention across a range of diseases.
| Item Type: | Articles |
|---|---|
| Keywords: | AIRWAY INFLAMMATION HUMAN MAST-CELLS IL-1-LIKE CYTOKINE IL-33 IN-VIVO INTERLEUKIN-1 RECEPTOR MYOCARDIAL-INFARCTION RECEPTOR ACCESSORY PROTEIN ST2 GENE-PRODUCT SUBARACHNOID HEMORRHAGE TH2 CELLS |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McInnes, Professor Iain and Liew, Prof Foo and Pitman, Dr Nick |
| Authors: | Liew, F. Y., Pitman, N. I., and McInnes, I. B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Nature Reviews Immunology |
| Publisher: | Nature Publishing Group |
| ISSN: | 1474-1733 |
| ISSN (Online): | 1474-1741 |
| Published Online: | 18 January 2010 |
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