Kwan, P., Arzimanoglou, A., Berg, A., Brodie, M.J.,, Hauser, W.A., Mathern, G., Moshe, S.L., Perucca, E., Wiebe, S. and French, J., (2010) Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia, 51(6), pp. 1069-1077. (doi: 10.1111/j.1528-1167.2009.02397.x)
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Abstract
P>To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant epilepsy. The overall framework of the definition has two "hierarchical" levels: Level 1 provides a general scheme to categorize response to each therapeutic intervention, including a minimum dataset of knowledge about the intervention that would be needed; Level 2 provides a core definition of drug resistant epilepsy using a set of essential criteria based on the categorization of response (from Level 1) to trials of antiepileptic drugs. It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom. This definition can be further refined when new evidence emerges. The rationale behind the definition and the principles governing its proper use are discussed, and examples to illustrate its application in clinical practice are provided.
| Item Type: | Articles |
|---|---|
| Keywords: | Antiepileptic drug Antiepileptic drugs ART BRAIN CARE CHILDHOOD-ONSET EPILEPSY CLINICAL-PRACTICE CNS DEFINITION Drug resistance Drugs Epilepsy FAILURE FOLLOW-UP ILAE INTERVENTION Intractable INTRACTABLE EPILEPSY LEVEL LONG MONOTHERAPY neurology PATIENT PEOPLE PERCEIVED IMPACT QUALITY-OF-LIFE RATIONALE Refractory REFRACTORY EPILEPSY Seizure STRATEGY SURGERY TASK TASK-FORCE TEMPORAL LOBECTOMY Treatment TRIAL trials |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Brodie, Professor Martin |
| Authors: | Kwan, P., Arzimanoglou, A., Berg, A., Brodie, M.J.,, Hauser, W.A., Mathern, G., Moshe, S.L., Perucca, E., Wiebe, S., and French, J., |
| College/School: | College of Arts & Humanities > School of Critical Studies > Scottish Literature |
| Journal Name: | Epilepsia |
| ISSN: | 0013-9580 |
| Published Online: | 03 November 2009 |
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