Obesity in pregnancy: prevalence and metabolic consequences

Huda, S. S., Brodie, L.E. and Sattar, N. (2010) Obesity in pregnancy: prevalence and metabolic consequences. Seminars in Fetal and Neonatal Medicine, 15(2), pp. 70-76. (doi:10.1016/j.siny.2009.09.006)

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Abstract

Rates of obesity have increased exponentially worldwide to almost epidemic proportions. This is associated with a marked increase in adverse maternal and perinatal outcomes and subsequent burden on health care resources. In particular, maternal obesity is linked to numerous metabolic complications including subfertility, gestational diabetes, hypertensive disorders of pregnancy and thromboembolism with potential long-term health consequences for both mother and child. The underlying pathophysiology linking maternal obesity and adverse outcomes is complex but is likely to involve alterations in glucose and lipid metabolism, inflammation, perturbances in adipokines and vascular dysfunction all seen in obese women. Intervention studies are underway to determine whether alteration of maternal lifestyle can improve maternal and fetal outcomes.

Item Type:Articles
Keywords:Adipokines ADIPOSE-TISSUE BODY-MASS INDEX CANCER CARE diabetes DYSFUNCTION ENGLAND Epidemiology EXCESSIVE WEIGHT-GAIN Free fatty acids Gestational diabetes GESTATIONAL DIABETES-MELLITUS GLUCOSE haemostasis HEALTH INCREASE inflammation Insulin resistance INSULIN-RESISTANCE INTERVENTION LIFE LONG-TERM LONGITUDINAL CHANGES MASS Maternal obesity MOTHERS NEURAL-TUBE DEFECTS Obesity outcome OUTCOMES PREGNANCY PREVALENCE RANDOMIZED CONTROLLED-TRIAL Scotland THROMBOEMBOLISM VISCERAL FAT weight WOMEN
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sattar, Professor Naveed and Huda, Dr Shahzya
Authors: Huda, S. S., Brodie, L.E., and Sattar, N.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Seminars in Fetal and Neonatal Medicine
ISSN:1744-165X

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