Helminth-derived immunomodulators: can understanding the worm produce the pill?

Harnett, W. and Harnett, M. M. (2010) Helminth-derived immunomodulators: can understanding the worm produce the pill? Nature Reviews Immunology, 10(4), pp. 278-284. (doi:10.1038/nri2730)

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Abstract

Helminths may protect humans against allergic and autoimmune diseases and, indeed, defined helminth-derived products have recently been shown to prevent the development of such inflammatory diseases in mouse models. Here, we propose that helminth-derived products not only have therapeutic potential but can also be used as unique tools for defining key molecular events in the induction of an anti-inflammatory response and, therefore, for defining new therapeutic targets

Item Type:Articles
Keywords:allergy autoimmune disease BLOOD C-TYPE LECTINS CONTAINING SECRETED PRODUCT CUTTING EDGE DENDRITIC CELL ACTIVATION DISEASE DISEASES DRIVES TH2 RESPONSES ENGLAND EVENTS HOST IMMUNE-RESPONSES Human HUMANS IN-VIVO INFLAMMATORY RESPONSES MODEL PRODUCT PROTEIN-KINASE Scotland TOLL-LIKE RECEPTORS
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Harnett, Professor Margaret
Authors: Harnett, W., and Harnett, M. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Reviews Immunology
ISSN:1474-1733

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