Effects of maternal obesity on fetal growth and body composition: implications for programming and future health

Freeman, D.J. (2010) Effects of maternal obesity on fetal growth and body composition: implications for programming and future health. Seminars in Fetal and Neonatal Medicine, 15(2), pp. 113-118. (doi: 10.1016/j.siny.2009.09.001)

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Abstract

Since the hypothesis linking low birth weight and poor fetal growth with future risk of cardiovascular disease was first proposed, there has been much interest in the early origins of disease. As rates of obesity increase and as maternal obesity has become common, interest has been directed towards the early origins of obesity. It is likely that a complex interaction of inherited gene effects and in-utero environment may interact in the developing fetus to programme pathways leading to future obesity. It is clear that maternal metabolism is disturbed in pregnancy in obese women, and that offspring of obese mothers have a higher percentage of body fat and are insulin resistant. This review discusses the ideas contributing to the current working concept of obesity programming, and discusses several potential mechanisms that may underlie obesity programming and susceptibility to future metabolic and vascular disease. (C) 2009 Elsevier Ltd. All rights reserved

Item Type:Articles
Keywords:ATHEROSCLEROSIS BIRTH-WEIGHT Body composition body fat BODY-COMPOSITION cardiovascular disease CARDIOVASCULAR-DISEASE CARE CORONARY-HEART-DISEASE diabetes DISEASE EARLY ATHEROSCLEROTIC LESIONS ENDOTHELIAL PROGENITOR CELLS ENGLAND ENVIRONMENT FAT GENE GLUCOKINASE GENE growth HEALTH hypertension IMPAIRED GLUCOSE-TOLERANCE IN-UTERO INCREASE insulin INTRAUTERINE ENVIRONMENT LOW-DENSITY-LIPOPROTEIN Maternal obesity MECHANISM Metabolism MOTHERS Obesity PATHWAY PREGNANCY Programming PROSPECTIVE COHORT RISK Scotland SUSCEPTIBILITY weight WOMEN
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Freeman, Dr Dilys
Authors: Freeman, D.J.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Seminars in Fetal and Neonatal Medicine
ISSN:1744-165X

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