Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions

Davidovici, B. B. et al. (2010) Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions. Journal of Investigative Dermatology, 130(7), pp. 1785-1796. (doi: 10.1038/jid.2010.103)

Abstract

Psoriasis is now classified as an immune-mediated inflammatory disease ( IMID) of the skin. It is being recognized that patients with various IMIDs, including psoriasis, are at higher risk of developing "systemic" co-morbidities, e.g., cardiovascular disease (CVD), metabolic syndrome, and overt diabetes. In non-psoriatic individuals, the pathophysiology of obesity, aberrant adipocyte metabolism, diabetes, and CVDs involves immune-mediated or inflammatory pathways. IMIDs may impact these co-morbid conditions through shared genetic risks, common environmental factors, or common inflammatory pathways that are co-expressed in IMIDs and target organs. Given that pathogenic immune pathways in psoriasis are now well worked out and a large number of inflammatory mediators have been identified in skin lesions, in this review we will consider possible mechanistic links between skin inflammation and increased risks of (1) obesity or metabolic alterations and (2) CVD. In particular, we will discuss how well-established risk factors for CVD can originate from inflammation in other tissues

• Item Type: Articles
• Keywords: ACTIVATED PROTEIN-KINASE ADIPOSE-TISSUE allergy ARTERY ATHEROSCLEROSIS cardiovascular disease CARDIOVASCULAR-DISEASE CARE CORONARY-HEART-DISEASE diabetes DISEASE DISEASES DOUBLE-EDGED-SWORD ENVIRONMENTAL-FACTORS FATTY-ACID OXIDATION GENE genes GROWTH-FACTOR-II haemostasis HUMAN ENDOTHELIAL-CELLS hypertension IMMUNE IMPACT INCREASED RISK INDIVIDUALS INDUCED INSULIN-RESISTANCE inflammation METABOLIC SYNDROME Metabolism NECROSIS-FACTOR BLOCKADE NF-KAPPA-B NUMBER Obesity PATHWAY PATIENT patients PSORIASIS RISK risk factors RISK-FACTOR RISK-FACTORS skin Syndrome TISSUE TRENDS
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Sattar, Professor Naveed
• Authors: Davidovici, B. B., Sattar, N., Jorg, P. C., Puig, L., Emery, P., Barker, J. N., van de Kerkhof, P., Stahle, M., Nestle, F. O., Girolomoni, G., and Krueger, J. G.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences
• Journal Name: Journal of Investigative Dermatology
• ISSN: 0022-202X