Chambers, J. C. et al. (2010) Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42(5), pp. 373-375. (doi: 10.1038/ng.566)
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Publisher's URL: http://dx.doi.org/10.1038/ng.566
Abstract
Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10<sup>−10</sup> to 10<sup>−15</sup>). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10<sup>−5</sup> and P = 3.6 × 10<sup>−4</sup>, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
Item Type: | Articles |
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Keywords: | ASSOCIATION Chronic DISEASE ENGLAND genetics GENOME-WIDE ASSOCIATION HEALTH OCT2 PATHWAY SERUM SUSCEPTIBILITY |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Connell, Professor John and Lagou, Miss Vasiliki and Dominiczak, Professor Anna |
Authors: | Chambers, J. C., Zhang, W., Lord, G., van der Harst, P., Lawlor, D. A., Sehmi, J. S., Gale, D. P., Wass, M. N., Ahmadi, K. R., Bakker, S. J. L., Beckmann, J., Bilo, H. J. G., Bochud, M., Brown, M. J., Caulfield, M. J., Connell, J. M. C., Cook, H. T., Cotlarciuc, I., Smith, G. D., de Silva, R., Deng, G., Devuyst, O., Dikkeschei, L. D., Dimkovic, N., Dockrell, M., Dominiczak, A., Ebrahim, S., Eggermann, T., Farrall, M., Ferrucci, L., Floege, J., Forouhi, N. G., Gansevoort, R. T., Han, X., Hedblad, B., van der Heide, J. J. H., Hepkema, B. G., Hernandez-Fuentes, M., Hypponen, E., Johnson, T., de Jong, P. E., Kleefstra, N., Lagou, V., Lapsley, M., Li, Y., Loos, R. J. F., Luan, J.'a., Luttropp, K., Marechal, C., Melander, O., Munroe, P. B., Nordfors, L., Parsa, A., Peltonen, L., Penninx, B. W., Perucha, E., Pouta, A., Prokopenko, I., Roderick, P. J., Ruokonen, A., Samani, N. J., Sanna, S., Schalling, M., Schlessinger, D., Schlieper, G., Seelen, M. A. J., Shuldiner, A. R., Sjogren, M., Smit, J. H., Snieder, H., Soranzo, N., Spector, T. D., Stenvinkel, P., Sternberg, M. J. E., Swaminathan, R., Tanaka, T., Ubink-Veltmaat, L. J., Uda, M., Vollenweider, P., Wallace, C., Waterworth, D., Zerres, K., Waeber, G., Wareham, N. J., Maxwell, P. H., McCarthy, M. I., Jarvelin, M.-R., Mooser, V., Abecasis, G. R., Lightstone, L., Scott, J., Navis, G., Elliott, P., and Kooner, J. S. |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Nature Genetics |
Publisher: | Nature Publishing Group |
ISSN: | 1061-4036 |
ISSN (Online): | 1546-1718 |
Published Online: | 11 April 2010 |
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