Complexities of oestrogen in stroke

Carswell, H.V.O., Macrae, I. M. and Farr, T.D. (2010) Complexities of oestrogen in stroke. Clinical Science, 118(5-6), pp. 375-389. (doi: 10.1042/CS20090018)

Abstract

Evidence exists for the potential protective effects of circulating ovarian hormones in stroke, and oestrogen reduces brain damage in animal ischaemia models. However, a recent clinical trial indicated that HRT (hormone-replacement therapy) increased the incidence of stroke in postmenopausal women, and detrimental effects of oestrogen on stroke outcome have been identified in a meta-analysis of HRT trials and in pre-clinical research studies. Therefore oestrogen is not an agent that can be promoted as a potential stroke therapy. Many published reviews have reported the neuroprotective effects of oestrogen in stroke, but have failed to include information on the detrimental effects. This issue is addressed in the present review, along with potential mechanisms of action, and the translational capacity of pre-clinical research

• Item Type: Articles
• Keywords: Aging BLOOD BRAIN breast cancer CANCER cardiovascular disease cerebrovascular system CNS CONJUGATED EQUINE ESTROGEN DENDRITIC SPINE DENSITY HEALTH INITIATIVE MEMORY HORMONE REPLACEMENT THERAPY hormone-replacement therapy Incidence MECHANISM METAANALYSIS MIDDLE CEREBRAL-ARTERY MODEL NITRIC-OXIDE SYNTHASE oestrogen outcome OVARIECTOMIZED FEMALE RATS PERMANENT FOCAL ISCHEMIA POSTMENOPAUSAL WOMEN RANDOMIZED CONTROLLED-TRIAL Scotland selective oestrogen receptor modulator (SERM) stroke THERAPY TRANSIENT FOREBRAIN ISCHEMIA TRIAL WOMEN
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Macrae, Professor Mhairi
• Authors: Carswell, H.V.O., Macrae, I. M., and Farr, T.D.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Clinical Science
• ISSN: 0143-5221