Benson, R.A. , Patakas, A., Conigliaro, P., Rush, C. M., Garside, P. , McInnes, I. B. and Brewer, J. M. (2010) Identifying the Cells Breaching Self-Tolerance in Autoimmunity. Journal of Immunology, 184(11), pp. 6378-6385. (doi: 10.4049/jimmunol.0903951) (PMID:20421640)
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Publisher's URL: http://www.jimmunol.org
Abstract
Activation of auto-reactive T cells by activated dendritic cells (DCs) presenting self-Ag is widely assumed to be the precipitating event in the development of autoimmune disease. However, despite such widely held preconceptions, supporting data are scarce and subjective, particularly in experimental arthropathy. We have adapted a novel murine model of breach of self-tolerance allowing evaluation of the contribution of endogenous DCs to the development of autoimmune responses and disease. For the first time, we reveal the critical role played by conventional DCs, and the timing and location of this process. We further demonstrate the importance of this finding by clinically relevant, therapeutic manipulation of conventional DC function, resulting in decreased autoimmune phenotype and disease severity. The Journal of Immunology, 2010, 184: 6378-6385
| Item Type: | Articles |
|---|---|
| Keywords: | ACTIVATION ANTIGEN autoimmune disease CELLS COLLAGEN-INDUCED ARTHRITIS DENDRITIC CELLS Development DISEASE EPSTEIN-BARR-VIRUS immunity IN-VIVO DEPLETION INDUCTION inflammation JOINT MODEL PHENOTYPE PLASMACYTOID DENDRITIC CELLS RESPONSES RHEUMATOID-ARTHRITIS Scotland SEVERITY T cells T-cell T-CELLS TNF-ALPHA |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McInnes, Professor Iain and Rush, Dr Catherine and Brewer, Professor James and Garside, Professor Paul and Benson, Dr Robert and Conigliaro, Dr Paola |
| Authors: | Benson, R.A., Patakas, A., Conigliaro, P., Rush, C. M., Garside, P., McInnes, I. B., and Brewer, J. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Immunology |
| Journal Abbr.: | J. Immunol. |
| ISSN: | 0022-1767 |
| ISSN (Online): | 1550-6606 |
| Published Online: | 26 April 2010 |
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