Calcium metabolism in eight dogs with hypoadrenocorticism

Gow, A.G., Gow, D.J., Bell, R., Simpson, J.W., Chandler, M.L., Evans, H., Berry, J.L., Herrtage, M.E. and Mellanby, R.J. (2009) Calcium metabolism in eight dogs with hypoadrenocorticism. Journal of Small Animal Practice, 50(8), pp. 426-430. (doi: 10.1111/j.1748-5827.2009.00757.x)

Abstract

Hypoadrenocorticism is a well-described endocrinopathy in dogs that results from deficient production and secretion of glucocorticoids and/or mineralocorticoids. Although hyperkalaemia, hyponatraemia and hypochloraemia are the most common electrolyte disturbances, hypercalcaemia also occurs in approximately 30 per cent of cases. The pathogenesis of hypercalcaemia in dogs with hypoadrenocorticism is unknown. This case series reports ionised calcium, parathyroid hormone, parathyroid hormone-related protein and vitamin D metabolite concentrations that were measured in eight dogs with concurrent hypercalcaemia and hypoadrenocorticism. Ionised calcium was increased in five of seven dogs with hypercalcaemia associated with hypoadrenocorticism. Parathyroid hormone, parathyroid hormone-related protein and 1,25 dihydroxyvitamin D concentrations were within their reference ranges in seven of eight dogs, six of seven cases and six of seven dogs, respectively. This case series highlights that hypercalcaemia associated with hypoadrenocorticism is rarely associated with increases in plasma parathyroid hormone, parathyroid hormone-related protein or serum 1,25 dihydroxyvitamin D concentrations

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Bell, Mr Rory
• Authors: Gow, A.G., Gow, D.J., Bell, R., Simpson, J.W., Chandler, M.L., Evans, H., Berry, J.L., Herrtage, M.E., and Mellanby, R.J.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Journal of Small Animal Practice
• Publisher: Wiley-Blackwell Publishing Ltd.
• ISSN: 0022-4510
• ISSN (Online): 1748-5827