Ellis, I.O., Dowsett, M., Bartlett, J., Walker, R., Cooke, T., Gullick, W., Gusterson, B., Mallon, E. and Lee, P.B. (2000) Recommendations for HER2 testing in the UK. Journal of Clinical Pathology, 53(12), pp. 890-892.
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Publisher's URL: http://jcp.bmjjournals.com/cgi/content/full/53/12/890
Abstract
Determining the HER2 status of breast carcinomas is a prerequisite for the use of the monoclonal antibody trastuzumab (Herceptin(R)), which has recently been licensed for the treatment of metastatic disease. This necessitates a test based on archival material. The preferred analyses are immunohistochemistry with fluorescent in situ hybridisation (FISH) as a follow up test for ambiguous results. Guidelines have been developed for standardised, well controlled procedures for the provision of reliable results. A group of three reference laboratories has been established to provide advice, quality assurance, and materials, where needed.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Gusterson, Professor Barry and Cooke, Prof Timothy |
Authors: | Ellis, I.O., Dowsett, M., Bartlett, J., Walker, R., Cooke, T., Gullick, W., Gusterson, B., Mallon, E., and Lee, P.B. |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RB Pathology |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Journal of Clinical Pathology |
Publisher: | BMJ Publishing Group Ltd. |
ISSN: | 0021-9746 |
Copyright Holders: | Copyright © 2001 by the Journal of Clinical Pathology and Association of Clinical Pathologists |
First Published: | First published in the Journal of Clinical Pathology 53(12):890-892 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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