Genetic aberrations of c-myc and CCND1 in the development of invasive bladder cancer

Watters, A.D., Latif, Z., Forsyth, A., Dunn, I., Underwood, M.A., Grigor, K.M. and Bartlett, J.M.S. (2002) Genetic aberrations of c-myc and CCND1 in the development of invasive bladder cancer. British Journal of Cancer, 87(6), pp. 654-658. (doi: 10.1038/sj.bjc.6600531)

Abstract

Detrusor muscle invasive transitional cell carcinoma is associated with poor prognosis and is responsible for the majority of bladder cancer related deaths. Amplifications of c- myc and CCNDI are associated with detrusor-muscle-invasive transitional cell carcinoma, however, their precise role in driving disease progression is unclear Fluorescence in situ hybridisation on archival tissue from 16 patients with primary diagnosis of greater than or equal topT2 transitional cell carcinoma and 15 cases with primary pTa/pTI disease subsequently progressing to detrusor-muscle-invasion was performed, in the latter group both pre and post muscle invasive events were studied. No patients presenting with greater than or equal topT2 had amplification of c-myc, two out of 16 (12.5%) had CCNDI amplification. Of patients who developed greater than or equal topT2, two out of 15 (13.3%) had amplification of c-myc, both in greater than or equal topT2, five out of 15 (33.3%) had CCNDI amplification, two in pTa/pTI tumours, three in greater than or equal topT2 transitional cell carcinomas. In total, two out of 31 (6.5%) of patients' greater than or equal topT2 TCCs were amplified for c-myc and six out of 31 (19%) were amplified for CCNDI. Eighty- seven per cent (40 out of 46) of tumours were polysomic for chromosome 8 and 80% (37 out of 46) were polysomic for chromosome II and this reflected the high copy numbers of c-myc and CCNDI observed. In almost all cases an increase in c- myc/CCNDI copy number occurred prior to invasion and persisted in advanced disease Amplification of CCNDI or alterations in c- myc/CCNDI early in bladder cancer may have clinical relevance in promoting and predicting progression to detrusor-muscle- invasive transitional cell carcinoma.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Underwood, Mr Mark
• Authors: Watters, A.D., Latif, Z., Forsyth, A., Dunn, I., Underwood, M.A., Grigor, K.M., and Bartlett, J.M.S.
• Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer); R Medicine > RB Pathology
• College/School: College of Medical Veterinary and Life Sciences
• Journal Name: British Journal of Cancer
• ISSN: 0007-0920