Kemi, O.J. and Wisløff, U. (2010) Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium. Acta Physiologica, 199(4), pp. 425-439. (doi: 10.1111/j.1748-1716.2010.02132.x)
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Abstract
One of the main outcomes of aerobic endurance exercise training is the improved maximal oxygen uptake, and this is pivotal to the improved work capacity that follows the exercise training. Improved maximal oxygen uptake in turn is at least partly achieved because exercise training increases the ability of the myocardium to produce a greater cardiac output. In healthy subjects, this has been demonstrated repeatedly over many decades. It has recently emerged that this scenario may also be true under conditions of an initial myocardial dysfunction. For instance, myocardial improvements may still be observed after exercise training in post-myocardial infarction heart failure. In both health and disease, it is the changes that occur in the individual cardiomyocytes with respect to their ability to contract that by and large drive the exercise training-induced adaptation to the heart. Here, we review the evidence and the mechanisms by which exercise training induces beneficial changes in the mammalian myocardium, as obtained by means of experimental and clinical studies, and argue that these changes ultimately alter the function of the whole heart and contribute to the changes in whole-body function.
Item Type: | Articles |
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Keywords: | Calcium, cardiomyocyte, exercise training, health and disease, intensity, myocardium |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Kemi, Dr Ole |
Authors: | Kemi, O.J., and Wisløff, U. |
Subjects: | Q Science > QP Physiology |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences |
Journal Name: | Acta Physiologica |
Publisher: | Wiley-Blackwell |
ISSN: | 1748-1708 |
ISSN (Online): | 1748-1716 |
Published Online: | 26 March 2010 |
Copyright Holders: | Copyright © 2010 Wiley-Blackwell |
First Published: | First published in Acta Physiologica 199(4):425-439 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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