Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium

Kemi, O.J. and Wisløff, U. (2010) Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium. Acta Physiologica, 199(4), pp. 425-439. (doi:10.1111/j.1748-1716.2010.02132.x)

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Abstract

One of the main outcomes of aerobic endurance exercise training is the improved maximal oxygen uptake, and this is pivotal to the improved work capacity that follows the exercise training. Improved maximal oxygen uptake in turn is at least partly achieved because exercise training increases the ability of the myocardium to produce a greater cardiac output. In healthy subjects, this has been demonstrated repeatedly over many decades. It has recently emerged that this scenario may also be true under conditions of an initial myocardial dysfunction. For instance, myocardial improvements may still be observed after exercise training in post-myocardial infarction heart failure. In both health and disease, it is the changes that occur in the individual cardiomyocytes with respect to their ability to contract that by and large drive the exercise training-induced adaptation to the heart. Here, we review the evidence and the mechanisms by which exercise training induces beneficial changes in the mammalian myocardium, as obtained by means of experimental and clinical studies, and argue that these changes ultimately alter the function of the whole heart and contribute to the changes in whole-body function.

Item Type:Articles
Keywords:Calcium, cardiomyocyte, exercise training, health and disease, intensity, myocardium
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kemi, Dr Ole
Authors: Kemi, O.J., and Wisløff, U.
Subjects:Q Science > QP Physiology
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences
Journal Name:Acta Physiologica
Publisher:Wiley-Blackwell
ISSN:1748-1708
ISSN (Online):1748-1716
Published Online:26 March 2010
Copyright Holders:Copyright © 2010 Wiley-Blackwell
First Published:First published in Acta Physiologica 199(4):425-439
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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