Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways

Thomson, N.R. et al. (2008) Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways. Genome Research, 18(10), pp. 1624-1637. (doi: 10.1101/gr.077404.108)

[img] Text
pubmed.html

4kB

Abstract

We have determined the complete genome sequences of a host-promiscuous Salmonella enterica serovar Enteritidis PT4 isolate P125109 and a chicken-restricted Salmonella enterica serovar Gallinarum isolate 287/91. Genome comparisons between these and other Salmonella isolates indicate that S. Gallinarum 287/91 is a recently evolved descendent of S. Enteritidis. Significantly, the genome of S. Gallinarum has undergone extensive degradation through deletion and pseudogene formation. Comparison of the pseudogenes in S. Gallinarum with those identified previously in other host-adapted bacteria reveals the loss of many common functional traits and provides insights into possible mechanisms of host and tissue adaptation. We propose that experimental analysis in chickens and mice of S. Enteritidis-harboring mutations in functional homologs of the pseudogenes present in S. Gallinarum could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Roberts, Professor Mark
Authors: Thomson, N.R., Clayton, D.J., Windhorst, D., Vernikos, G., Davidson, S., Churcher, C., Quail, M.A., Stevens, M., Jones, M.A., Watson, M., Barron, A., Layton, A., Pickard, D., Kingsley, R.A., Bignell, A., Clark, L., Harris, B., Ormond, D., Abdellah, Z., Brooks, K., Cherevach, I., Chillingworth, T., Woodward, J., Norberczak, H., Lord, A., Arrowsmith, C., Jagels, K., Moule, S., Mungall, K., Sanders, M., Whitehead, S., Chabalgoity, J.A., Maskell, D., Humphrey, T., Roberts, M., Barrow, P.A., Dougan, G., and Parkhill, J.
Subjects:Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Genome Research
ISSN:1088-9051
ISSN (Online):1549-5469
Published Online:26 June 2008

University Staff: Request a correction | Enlighten Editors: Update this record