Disturbing visual working memory: Electrophysiological evidence for a role of prefrontal cortex in recovery from interference

Kessler, K. and Kiefer, M. (2005) Disturbing visual working memory: Electrophysiological evidence for a role of prefrontal cortex in recovery from interference. Cerebral Cortex(15), pp. 1075-1087.

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Abstract

Single cell recordings in monkeys support the notion that the lateral prefrontal cortex (PFC) controls reactivation of visual working memory representations when rehearsal is disrupted. In contrast, recent fMRI findings yielded a double dissociation for PFC and the medial temporal lobe (MTL) in a letter working memory task. PFC was engaged in interference protection during reactivation while MTL was prominently involved in the retrieval of the letter representations. We present event-related potential data (ERP) that support PFC involvement in the top-down control of reactivation during a visual working memory task with endogenously triggered recovery after visual interference. A differentiating view is proposed for the role of PFC in working memory with respect to endogenous/exogenous control and to stimulus type. General implications for binding and retention mechanisms are discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kessler, Dr Klaus
Authors: Kessler, K., and Kiefer, M.
College/School:College of Science and Engineering > School of Psychology
College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Cerebral Cortex

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