Real world study of sacituzumab govitecan in metastatic triple-negative breast cancer in the United Kingdom

Hanna, D. et al. (2024) Real world study of sacituzumab govitecan in metastatic triple-negative breast cancer in the United Kingdom. British Journal of Cancer, (doi: 10.1038/s41416-024-02685-9) (Early Online Publication)

Abstract

Background: Treatment options for pre-treated patients with metastatic triple-negative breast cancer (mTNBC) remain limited. This is the first study to assess the real-world safety and efficacy of sacituzumab govitecan (SG) in the UK. Methods: Data was retrospectively collected from 16 tertiary UK cancer centres. Pts had a diagnosis of mTNBC, received at least two prior lines of treatment (with at least one being in the metastatic setting) and received at least one dose of SG. Results: 132 pts were included. Median age was 56 years (28–91). All patients were ECOG performance status (PS) 0-3 (PS0; 39, PS1; 76, PS2; 16, PS3;1). 75% (99/132) of pts had visceral metastases including 18% (24/132) of pts with CNS disease. Median PFS (mPFS) was 5.2 months (95% CI 4.5–6.6) with a median OS (mOS) of 8.7 months (95% CI 6.8-NA). The most common adverse events (AEs) were fatigue (all grade; 82%, G3/4; 14%), neutropenia (all grade; 55%, G3/4; 29%), diarrhoea (all grade; 58%, G3/4, 15%), and nausea (all grade; 38%, G3/4; 3%). SG dose reduction was required in 54% of pts. Conclusion: This study supports significant anti-tumour activity in heavily pre-treated pts with mTNBC. Toxicity data aligns with clinical trial experience.

• Item Type: Articles
• Status: Early Online Publication
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: ROSS, Dr KIRSTY and MacPherson, Professor Iain
• Authors: Hanna, D., Merrick, S., Ghose, A., Devlin, M. J., Yang, D. D., Phillips, E., Okines, A., Chopra, N., Papadimatraki, E., ROSS, K., MacPherson, I., Boh, Z. Y., Michie, C. O., Swampillai, A., Gupta, S., Robinson, T., Germain, L., Twelves, C., Atkinson, C., Konstantis, A., Riddle, P., Cresti, N., Naik, J. D., Borley, A., Guppy, A., Schmid, P., and Phillips, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: British Journal of Cancer
• Publisher: Nature Publishing Group
• ISSN: 0007-0920
• ISSN (Online): 1532-1827
• Published Online: 24 April 2024
• Copyright Holders: Copyright © The Author(s) 2024
• First Published: First published in British Journal of Cancer 2024
• Publisher Policy: Reproduced under a Creative Commons licence