Wei, J. et al. (2024) Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population. Nature Communications, 15, 1008. (doi: 10.1038/s41467-024-44973-1) (PMID:38307854) (PMCID:PMC10837445)
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Abstract
SARS-CoV-2 reinfections increased substantially after Omicron variants emerged. Large-scale community-based comparisons across multiple Omicron waves of reinfection characteristics, risk factors, and protection afforded by previous infection and vaccination, are limited. Here we studied ~45,000 reinfections from the UK’s national COVID-19 Infection Survey and quantified the risk of reinfection in multiple waves, including those driven by BA.1, BA.2, BA.4/5, and BQ.1/CH.1.1/XBB.1.5 variants. Reinfections were associated with lower viral load and lower percentages of self-reporting symptoms compared with first infections. Across multiple Omicron waves, estimated protection against reinfection was significantly higher in those previously infected with more recent than earlier variants, even at the same time from previous infection. Estimated protection against Omicron reinfections decreased over time from the most recent infection if this was the previous or penultimate variant (generally within the preceding year). Those 14–180 days after receiving their most recent vaccination had a lower risk of reinfection than those >180 days from their most recent vaccination. Reinfection risk was independently higher in those aged 30–45 years, and with either low or high viral load in their most recent previous infection. Overall, the risk of Omicron reinfection is high, but with lower severity than first infections; both viral evolution and waning immunity are independently associated with reinfection.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Hay, Dr Jodie and Vansteenhouse, Dr Harper and Conway, Professor David |
Authors: | Wei, J., Stoesser, N., Matthews, P. C., Khera, T., Gethings, O., Diamond, I., Studley, R., Taylor, N., Peto, T. E. A., Walker, A. S., Pouwels, K. B., Eyre, D. W., Rourke, E., Thomas, T., Pienaar, D., Preece, J., Crofts, S., Lloyd, L., Bowen, M., Ayoubkhani, D., Black, R., Felton, A., Crees, M., Jones, J., Sutherland, E., Crook, D. W., Pritchard, E., Vihta, K.-D., Howarth, A., Marsden, B. D., Chau, K. K., Ferreira, L. M., Dejnirattisai, W., Mongkolsapaya, J., Hoosdally, S., Cornall, R., Stuart, D. I., Screaton, G., Lythgoe, K., Bonsall, D., Golubchik, T., Fryer, H., Newton, J. N., Bell, J. I., Cox, S., Paddon, K., James, T., House, T., Robotham, J., Birrell, P., Jordan, H., Sheppard, T., Athey, G., Moody, D., Curry, L., Brereton, P., Jarvis, I., Godsmark, A., Morris, G., Mallick, B., Eeles, P., Hay, J., VanSteenhouse, H., Lee, J., White, S., Evans, T., Bloemberg, L., Allison, K., Pandya, A., Davis, S., Conway, D. I., MacLeod, M., and Cunningham, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
Journal Name: | Nature Communications |
Publisher: | Nature Research |
ISSN: | 2041-1723 |
ISSN (Online): | 2041-1723 |
Copyright Holders: | Copyright © 2024 The Authors |
First Published: | First published in Nature Communications 15:1008 |
Publisher Policy: | Reproduced under a Creative Commons licence |
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