Cuahtecontzi Delint, R., Jaffery, H., Ishak, M. I., Nobbs, A. H., Su, B. and Dalby, M. J. (2024) Mechanotransducive surfaces for enhanced cell osteogenesis, a review. Biomaterials Advances, (doi: 10.1016/j.bioadv.2024.213861) (In Press)
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Abstract
Novel strategies employing mechano-transducing materials eliciting biological outcomes have recently emerged for controlling cellular behaviour. Targeted cellular responses are achieved by manipulating physical, chemical, or biochemical modification of material properties. Advances in techniques such as nanopatterning, chemical modification, biochemical molecule embedding, force-tuneable materials, and artificial extracellular matrices are helping understand cellular mechanotransduction. Collectively, these strategies manipulate cellular sensing and regulate signalling cascades including focal adhesions, YAP-TAZ transcription factors, and multiple osteogenic pathways. In this minireview, we are providing a summary of the influence that these materials, particularly titanium-based orthopaedic materials, have on cells. We also highlight recent complementary methodological developments including, but not limited to, the use of metabolomics for identification of active biomolecules that drive cellular differentiation.
| Item Type: | Articles |
|---|---|
| Keywords: | Mechanotransduction, stem cell, osteogenesis, YAP-TAZ, metabolomics, nanotopography, titanium implants, bone. |
| Status: | In Press |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Dalby, Professor Matthew and Cuahtecontzi Delint, Dr Rosalia and Jaffery, Dr Hussain |
| Creator Roles: | Cuahtecontzi Delint, R.Writing – review and editing, Writing – original draft, Conceptualization Jaffery, H.Writing – review and editing, Writing – original draft, Conceptualization Dalby, M. J.Writing – review and editing, Writing – original draft, Supervision, Conceptualization |
| Authors: | Cuahtecontzi Delint, R., Jaffery, H., Ishak, M. I., Nobbs, A. H., Su, B., and Dalby, M. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Biomaterials Advances |
| Publisher: | Elsevier |
| ISSN: | 2772-9516 |
| ISSN (Online): | 2772-9508 |
| Published Online: | 15 April 2024 |
| Copyright Holders: | Copyright © 2024 The Authors |
| First Published: | First published in Biomaterials Advances 2024 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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