Association of a dietary inflammatory index with cardiometabolic, endocrine, liver, renal and bones biomarkers: cross-sectional analysis of the UK Biobank study

Carrasco-Marín, F. et al. (2024) Association of a dietary inflammatory index with cardiometabolic, endocrine, liver, renal and bones biomarkers: cross-sectional analysis of the UK Biobank study. Nutrition, Metabolism and Cardiovascular Diseases, (doi: 10.1016/j.numecd.2024.03.010) (In Press)

Abstract

Background and Aims: Research into the relationship between an Energy-adjusted Diet-Inflammatory Index (E-DII) and a wider health-related biomarkers profile is limited. Much of the existing evidence centers on traditional metabolic biomarkers in populations with chronic diseases, with scarce data on healthy individuals. Thus, this study aims to investigate the association between an E-DII score and 30 biomarkers spanning metabolic health, endocrine, bone health, liver function, cardiovascular, and renal functions, in healthy individuals. Methods and Results: 66,978 healthy UK Biobank participants, the overall mean age was 55.3 (7.9) years were included in this cross-sectional study. E-DII scores, based on 18 food parameters, were categorized as anti-inflammatory (E-DII <-1), neutral (-1 to 1), and pro-inflammatory (>1). Regression analyses, adjusted for confounding factors, were conducted to investigate the association of 30 biomarkers with E-DII. Compared to those with an anti-inflammatory diet, individuals with a pro-inflammatory diet had increased levels of 16 biomarkers, including six cardiometabolic, five liver, and four renal markers. The concentration difference ranged from 0.27 SD for creatinine to 0.03 SD for total cholesterol. Conversely, those on a pro-inflammatory diet had decreased concentrations in six biomarkers, including two for endocrine and cardiometabolic. The association range varied from -0.04 for IGF-1 to -0.23 for SHBG. Conclusion: This study highlighted that a pro-inflammatory diet was associated with an adverse profile of biomarkers linked to cardiometabolic health, endocrine, liver function, and renal health.

• Item Type: Articles
• Additional Information: UK Biobank was established by the Wellcome Trust, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government and the British Heart Foundation.
• Keywords: Diet inflammatory index, biomarkers, diet.
• Status: In Press
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Celis, Dr Carlos and Ho, Dr Frederick and Ferguson, Dr Lyn and Pell, Professor Jill and Hebert, Professor James and Petermann-Rocha, Mrs Fanny and Carrasco Marín, Mrs Fernanda
• Authors: Carrasco-Marín, F., Zhao, L., Hébert, J. R., Wirth, M. D., Petermann-Rocha, F., Phillips, N., Malcomson, F. C., Mathers, J. C., Ferguson, L. D., Ho, F., Pell, J., Celis-Morales, C., Molina-Recio, G., and Molina-Luque, R.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
• Journal Name: Nutrition, Metabolism and Cardiovascular Diseases
• Publisher: Elsevier
• ISSN: 0939-4753
• ISSN (Online): 1590-3729
• Published Online: 14 March 2024
• Copyright Holders: Copyright © 2024 The Authors
• First Published: First published in Nutrition, Metabolism and Cardiovascular Diseases 2024
• Publisher Policy: Reproduced under a Creative Commons License