Milling, S. , Yrlid, U., Cerovic, V. and MacPherson, G. (2010) Subsets of migrating intestinal dendritic cells. Immunological Reviews, 234(1), pp. 259-267. (doi: 10.1111/j.0105-2896.2009.00866.x)
Text
32241.pdf 1MB |
Publisher's URL: http://dx.doi.org/10.1111/j.0105-2896.2009.00866.x
Abstract
Dendritic cells (DCs) in the intestine are heterogeneous. Phenotypically different populations of conventional DCs have been identified in the intestinal lamina propria, Peyer's patches, and in the draining mesenteric lymph nodes, to which these DCs constitutively migrate. Markers used to identify these populations include major histocompatibility complex class II, CD11c, CD8α, CD11b, and CD103. Extensive studies in rats, summarized here, which involved collection of migrating DCs by thoracic duct cannulation after mesenteric lymphadenectomy, have clearly demonstrated that the subsets of migrating intestinal lymph DCs have different functional properties. The subsets might play different roles in the induction of oral tolerance and in driving systemic immune responses after vaccination or intestinal stimulation with Toll-like receptor ligands. The use of these surgical techniques allows investigation of the functions of purified subsets of migrating DCs. However, in the rat, these studies are limited by the range of available reagents and are difficult to compare with data from other species in this fast-moving field. Recent refinements have enabled the collection of migrating intestinal DCs from mice; our initial results are described here. We believe that these studies will generate exciting data and have the potential to resolve important questions about the functions of migrating intestinal DC subsets.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Milling, Professor Simon |
Authors: | Milling, S., Yrlid, U., Cerovic, V., and MacPherson, G. |
Subjects: | Q Science > QR Microbiology |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Immunological Reviews |
Publisher: | John Wiley and Sons |
ISSN: | 0105-2896 |
ISSN (Online): | 1600-065X |
Published Online: | 22 February 2010 |
Copyright Holders: | Copyright © 2010 John Wiley and Sons |
First Published: | First published in Immunological Reviews 234(1):259-267 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher. |
Related URLs: |
University Staff: Request a correction | Enlighten Editors: Update this record