Synthesis of the trichloroacetamide derivative of enantio-iso-ADDA methyl ester

Meiries, S., Parkin, A. and Marquez, R. (2009) Synthesis of the trichloroacetamide derivative of enantio-iso-ADDA methyl ester. Tetrahedron, 65(15), pp. 2951-2958. (doi: 10.1016/j.tet.2009.02.004)

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Abstract

The divergent syntheses of the trichloroacetamide derivatives of (2S,3R,8R,9R,4E,6E)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-decadenoic acid (enantio-iso-ADDA), and (2R,3R,8R,9R,4E,6E)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-decadenoic acid (enantio-ADDA), have been achieved. Our approach takes advantage of highly efficient non-aldol aldol, palladium catalysed aza-Claisen and cross-metathesis methodologies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Marquez, Dr Rudi and Meiries, Mr Sebastien and Parkin, Dr Andrew
Authors: Meiries, S., Parkin, A., and Marquez, R.
Subjects:Q Science > QD Chemistry
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Tetrahedron
ISSN:0040-4020
ISSN (Online):1464-5416
Published Online:11 February 2009

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