Quin, C., Trnka, J., Hay, A., Murphy, M.P. and Hartley, R.C. (2009) Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization. Tetrahedron, 65(39), pp. 8154-8160. (doi: 10.1016/j.tet.2009.07.081) (PMID:19888470) (PMCID:PMC2767131)
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Abstract
A new cyclic nitrone spin trap, [4-(3′,3′-dibutyl-2′-oxy-3′H-isoindol-5′-yloxy)butyl]triphenylphosphonium bromide (MitoSpin), bearing a lipophilic cation has been prepared by a route that involves a novel Parham-type lithiation–cyclization of an isocyanate to give the isoindolinone core. MitoSpin accumulates in a membrane potential dependent way in energized mitochondria and its oxidation could potentially be used in the study of oxidative stress resulting from reactive oxygen species generated in mitochondria.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Hartley, Professor Richard |
Authors: | Quin, C., Trnka, J., Hay, A., Murphy, M.P., and Hartley, R.C. |
Subjects: | Q Science > QD Chemistry |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Tetrahedron |
Publisher: | Elsevier |
ISSN: | 0040-4020 |
ISSN (Online): | 1464-5416 |
Published Online: | 06 August 2009 |
Copyright Holders: | Copyright © 2009 Elsevier |
First Published: | First published in Tetrahedron 65(39):8154-8160 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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