Maddipatla, S. P., McLoone, P. , Puxty, K. and McGovern, C. (2024) The incidence of cancer following hospitalisation for a burn injury in Scotland 2009-2019: A retrospective cohort study. Burns, (doi: 10.1016/j.burns.2024.02.029) (In Press)
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Abstract
Background Studies have suggested an increased occurrence of cancer in individuals who have experienced a burn injury requiring hospital admission. Objective To determine the incidence of cancer among individuals hospitalised for burn injuries in Scotland compared with a similar group without a history of burn injury hospitalisation. Method A retrospective cohort design was used to compare cancer (ICD10 C00–97, excluding C44) incidence in two groups: 6805 burn injury patients discharged from Scottish hospitals between 2009 and 2019, and 25,946 subjects from the general population who were matched to burn patients by sex, year of birth, and degree of social deprivation. Cancer incidence was identified from the Scottish cancer registry. Cox proportional hazard regression was used to model time to cancer incidence adjusting for age, sex, degree of deprivation and presence of a comorbidity. Cancer risk was presented as standardised incidence ratios (SIRs) and hazard ratios (HR). Results There was a higher prevalence of pre-existing conditions, particularly alcohol abuse among patients with burns. Pre-existing cancers were more common in the burn cohort (3.5%) than the comparison group (1.7%) and were excluded from further analysis. Over a median follow-up of 4–5 years, a total of 236 (3.5%) burn patients and 969 (3.7%) individuals in the comparison group were diagnosed with cancer. At 0–6 months the cancer SIR for burn patients was 1.88 95% CI (1.40–2.52). After excluding the first six months of follow-up, the overall incidence of cancer was marginally elevated in burn patients (SIR 1.04, 95% CI 0.90–1.19, p = 0.62) and not statistically different from the incidence in comparison subjects (adjusted HR 1.03, 95% CI 0.88–1.21, p = 0.71). Conclusions Patients that suffer burn injury have a higher incidence of cancer than the general population and a group matched by age, sex and degree of deprivation. A higher incidence of adverse health-related behaviours such as smoking, alcohol use and pre-existing health conditions among many patients that suffer a burn most likely explain this observed increase. Any persisting inflammatory or immune dysfunction following burn injury is unlikely to account for the increase in cancers in this study.
| Item Type: | Articles |
|---|---|
| Additional Information: | This study was funded by joint research grants from the Association of Anaesthetists charitable arm, the AAGBI Foundation via the National Institute of Academic Anaesthesia (NIAA19R213) and the NHS Greater Glasgow and Clyde Endowment Fund (GN19AE535). |
| Status: | In Press |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McLoone, Mr Philip and Puxty, Dr Kathryn and McGovern, Dr Christopher |
| Creator Roles: | McLoone, P.Methodology, Formal analysis, Writing – review and editing McGovern, C.Conceptualization, Methodology, Funding acquisition, Writing – review and editing Puxty, K.Conceptualization, Methodology, Funding acquisition, Writing – review and editing |
| Authors: | Maddipatla, S. P., McLoone, P., Puxty, K., and McGovern, C. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Burns |
| Publisher: | Elsevier |
| ISSN: | 0305-4179 |
| Published Online: | 01 March 2024 |
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