Metzner, C., Dimulescu, C., Kamp, F., Fromm, S., Uhlhaas, P. J. and Obermayer, K. (2024) Exploring global and local processes underlying alterations in resting-state functional connectivity and dynamics in schizophrenia. Frontiers in Psychiatry, 15, 1352641. (doi: 10.3389/fpsyt.2024.1352641) (PMID:38414495) (PMCID:PMC10897003)
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Abstract
Introduction: We examined changes in large-scale functional connectivity and temporal dynamics and their underlying mechanisms in schizophrenia (ScZ) through measurements of resting-state functional magnetic resonance imaging (rs-fMRI) data and computational modelling. Methods: The rs-fMRI measurements from patients with chronic ScZ (n=38) and matched healthy controls (n=43), were obtained through the public schizConnect repository. Computational models were constructed based on diffusion-weighted MRI scans and fit to the experimental rs-fMRI data. Results: We found decreased large-scale functional connectivity across sensory and association areas and for all functional subnetworks for the ScZ group. Additionally global synchrony was reduced in patients while metastability was unaltered. Perturbations of the computational model revealed that decreased global coupling and increased background noise levels both explained the experimentally found deficits better than local changes to the GABAergic or glutamatergic system. Discussion: The current study suggests that large-scale alterations in ScZ are more likely the result of global rather than local network changes.
Item Type: | Articles |
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Additional Information: | The author(s) declare financial support was received for the research, authorship, and/or publication of this article. CM and PU were supported through the Einstein Stiftung Berlin (A-2020-613). Data collection and sharing for this project was funded by NIMH cooperative agreement 1U01 MH097435. Data was downloaded from the COllaborative Informatics and Neuroimaging Suite Data Exchange tool (COINS; http://coins.mrn.org/dx) and data collection was performed at the Mind Research Network, and funded by a Center of Biomedical Research Excellence (COBRE) grant 5P20RR021938/P20GM103472 from the NIH to Dr. Vince Calhoun. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Uhlhaas, Professor Peter |
Creator Roles: | |
Authors: | Metzner, C., Dimulescu, C., Kamp, F., Fromm, S., Uhlhaas, P. J., and Obermayer, K. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Frontiers in Psychiatry |
Publisher: | Frontiers Media |
ISSN: | 1664-0640 |
ISSN (Online): | 1664-0640 |
Copyright Holders: | Copyright © 2024 Metzner, Dimulescu, Kamp, Fromm, Uhlhaas and Obermayer |
First Published: | First published in Frontiers in Psychiatry 15:1352641 |
Publisher Policy: | Reproduced under a Creative Commons license |
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