Multi-system investigation of COVID-19 illness

Mangion, K. et al. (2022) Multi-system investigation of COVID-19 illness. British Cardiovascular Society Annual Conference, ‘100 years of Cardiology’, Manchester, UK, 06-08 June 2022. A122.1-A122. (doi: 10.1136/heartjnl-2022-BCS.157)

Full text not currently available from Enlighten.

Abstract

Introduction The pathophysiology and trajectory of multiorgan involvement in post-COVID-19 syndrome is uncertain. We aimed to adjudicate the likelihood of myocarditis in post-COVID-19 patients. Methods A prospective, longitudinal, cohort study involving post-COVID-19 patients enrolled in-hospital or early post-discharge (visit 1) and re-evaluated 28–60 days post-discharge (visit 2). Serial research blood tests (biomarkers), digital electrocardiography, and patient reported outcome measures were obtained at both visits. Chest computed tomography with pulmonary and coronary angiography, cardiovascular and renal magnetic resonance imaging, were acquired at visit 2. Results 159 patients (mean age 55 years, 43% female) and 27 controls with similar age, sex, ethnicity, and vascular risk factors were enrolled from 22 May 2020 to 2 July 2021 and had a primary outcome evaluation. Adjudicated likelihood of myocarditis was not (n=17; 11%), unlikely (n=56; 35%), probably (n=65; 41%) or very likely (n=21; 13%). Healthcare worker status (odds ratio, 95% confidence interval: 2.99 (1.01, 8.89); p=0.048), acute kidney injury (3.26 (1.00, 10.64); p=0.050) and HbA1c(0.64 (0.42, 0.99); p=0.044) were multivariable associates of adjudicated myocarditis. During convalescence, COVID-19 was associated with worse health-related quality of life (EQ5D-5L) (p<0.001), illness perception (p<0.001), anxiety and depression (p<0.001), physical activity (p<0.001) and predicted maximal oxygen utilization (ml/kg/min) (p<0.001). These measures were associated with adjudicated myocarditis. Conclusion The illness trajectory of COVID-19 includes persisting cardio-renal inflammation, lung damage and hemostasis activation. Adjudicated myocarditis occurred in one in eight hospitalized patients and was associated with impairments in health status, physical and psychological wellbeing during community convalescence.

Item Type:Conference or Workshop Item
Additional Information:Abstract published in Heart 108(Suppl1): A122
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Veldtman, Professor Gruschen and Carrick, Dr David and Bulluck, Dr Heerajnarain and Corcoran, Dr David and Mangion, Dr Kenneth and Morrow, Dr Andrew and Findlay, Dr Iain and Nordin, Dr Sabrina and Roditi, Dr Giles and Sykes, Dr Robert and Bayes, Dr Hannah and McConnachie, Professor Alex and Mark, Professor Patrick and Welsh, Professor Paul and McIntosh, Dr Alasdair and Ho, Dr Antonia and Watkins, Dr Stuart and Bagot, Dr Catherine and Berry, Professor Colin and Hall Barrientos, Dr Pauline and Lang, Professor Ninian and Payne, Dr Alexander
Authors: Mangion, K., Morrow, A., Sykes, R., McIntosh, A., Bagot, C., Bayes, H. K., Bulluck, H., Carrick, D., Corcoran, D., Findlay, I., Hall Barrientos, P., Ho, A., Lang, N. N., Lennie, V., Mark, P., McConnachie, A., McGeoch, R., Nordin, S., Payne, A., Ryan, N., Roditi, G., Allwood-Speirs, S., Veldtman, G., Watkins, S., Welsh, P., and Berry, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
ISSN:1355-6037

University Staff: Request a correction | Enlighten Editors: Update this record