Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study

Berry, C. et al. (2023) Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study. Heart and Mind, 7(4), pp. 235-245. (doi: 10.4103/hm.HM-D-23-00037)

Abstract

Background: The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain. Objectives: This article will investigate the associations between baseline mental health status and disease trajectory following COVID-19 hospitalization, which may have implications for practice and future research. Methods: The Chief Scientist Office Cardiovascular and Pulmonary Imaging in severe acute respiratory syndrome (SARS) COVID-19 study is a prospective, observational, multicenter, longitudinal, secondary care cohort study that assessed the time-course of multi-organ injury in posthospital survivors of COVID-19. Patients were assessed in-hospital, at 28–60 days after discharge and in the longer term using electronic health record linkage. Results: One hundred and fifty-two patients (mean ± standard deviation [SD] age 54.3 ± 11.8 years, 43% female, 40% most socio-economically deprived quintile, 33% history of mental health history) were enrolled and had mental health serially assessed using the Patient Health Questionnaire-4 (PHQ-4) questionnaire. Fifty-three (35%) had PHQ-4 score of 6–12 consistent with moderate-severe symptoms of anxiety or depression and this was associated with diagnostic criteria for myocarditis (P = 0.0498). Moderate-severe symptoms of anxiety or depression were positively associated with higher perception of illness, lower health-related quality of life (HRQoL), and poorer physical function. The mean (SD) duration of follow-up after hospital discharge was 428 (86) days (range, 290–627 days). PHQ-4 score was not associated with clinical outcomes at follow-up. Conclusions: In patients who have been hospitalized with COVID-19, moderate-severe symptoms of anxiety or depression were associated with myocarditis, worse HRQoL, higher perception of illness, and lower levels of physical function.

• Item Type: Articles
• Additional Information: The MRI study involved technologies provided by Siemens Healthcare and the National Institutes of Health. HeartFlow (HeartFlow, Redwood City, CA) provided FFRCT. The study was co‑sponsored by National Health Service Greater Glasgow and Clyde Health Board and the University of Glasgow.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Macfarlane, Professor Peter and Veldtman, Professor Gruschen and Robertson, Dr Keith and Carrick, Dr David and Church, Dr Colin and Bulluck, Dr Heerajnarain and Corcoran, Dr David and Gibson, Dr Vivienne and Mangion, Dr Kenneth and Morrow, Dr Andrew and Findlay, Dr Iain and Nordin, Dr Sabrina and Blyth, Professor Kevin and Roditi, Dr Giles and Weeden, Dr Sarah and Sykes, Dr Robert and Bayes, Dr Hannah and Kamdar, Anna and McConnachie, Professor Alex and Mark, Professor Patrick and Welsh, Professor Paul and Gillespie, Dr Lynsey and Ho, Dr Antonia and Rankin, Dr Alastair and Lowe, Dr David and Watkins, Dr Stuart and Bagot, Dr Catherine and Touyz, Professor Rhian and Berry, Professor Colin and Mayne, Dr Kaitlin and Allwood-Spiers, Sarah and Lang, Professor Ninian and Payne, Dr Alexander and Sattar, Professor Naveed
• Authors: Berry, C., Lomholt-Welch, H., Morrow, A. J., Sykes, R., Saleh, M., Zahra, B., MacIntosh, A., Kamdar, A., Bagot, C., Bayes, H. K., Blyth, K. G., Bulluck, H., Carrick, D., Church, C., Corcoran, D., Findlay, I., Gibson, V. B., Gillespie, L., Grieve, D., Barrientos, P. H., Ho, A., Lang, N. N., Lowe, D. J., Lennie, V., Macfarlane, P. W., Mayne, K., Mark, P. B., McConnachie, A., McGeoch, R., Nordin, S., Payne, A., Rankin, A. J., Robertson, K., Ryan, N., Roditi, G., Sattar, N., Stobo, D., Allwood-Spiers, S., Touyz, R. M., Veldtman, G., Weeden, S., Weir, R., Watkins, S., Welsh, P., and Mangion, K.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care; College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Heart and Mind
• Publisher: Medknow Publications
• ISSN: 2468-6476
• ISSN (Online): 2468-6484
• Copyright Holders: Copyright: © 2023 Heart and Mind
• First Published: First published in Heart and Mind 7(4): 235-245
• Publisher Policy: Reproduced under a Creative Commons licence