The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function

Ramirez, G. A. et al. (2018) The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function. Journal of Neuroimmunology, 325, pp. 43-53. (doi: 10.1016/j.jneuroim.2018.10.010) (PMID:30384327)

Abstract

Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Cells from TT patients with NPSLE were more dependent on TRPC6 for the generation of calcium currents.

• Item Type: Articles
• Additional Information: The authors gratefully acknowledge the support of the Fondazione Cariplo to the project FRASNET (“Network per lo studio dell'invecchiamento renale e della sarcopenia: approccio combinato genetico, immunologico e psicologico per comprendere la fragilità”; Grant Fondazione Cariplo 2016-0980).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Coletto, Ms Lavinia
• Authors: Ramirez, G. A., Coletto, L. A., Bozzolo, E. P., Citterio, L., Delli Carpini, S., Zagato, L., Rovere-Querini, P., Lanzani, C., Manunta, P., Manfredi, A. A., and Sciorati, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Journal of Neuroimmunology
• Publisher: Elsevier
• ISSN: 0165-5728
• Published Online: 23 October 2018