The role of neutrophils in Spondyloarthritis: a journey across the spectrum of disease manifestations

Coletto, L. A., Rizzo, C., Guggino, G., Caporali, R., Alivernini, S. and Antonietta D’Agostino, M. (2023) The role of neutrophils in Spondyloarthritis: a journey across the spectrum of disease manifestations. International Journal of Molecular Sciences, 24(4), 4108. (doi: 10.3390/ijms24044108) (PMID:36835520) (PMCID:PMC9959122)

Abstract

Spondyloarthritis (SpA) contemplates the inflammatory involvement of the musculoskeletal system, gut, skin, and eyes, delineating heterogeneous diseases with a common pathogenetic background. In the framework of innate and adaptive immune disruption in SpA, neutrophils are arising, across different clinical domains, as pivotal cells crucial in orchestrating the pro-inflammatory response, both at systemic and tissue levels. It has been suggested they act as key players along multiple stages of disease trajectory fueling type 3 immunity, with a significant impact in the initiation and amplification of inflammation as well as in structural damage occurrence, typical of long-standing disease. The aim of our review is to focus on neutrophils’ role within the spectrum of SpA, dissecting their functions and abnormalities in each of the relevant disease domains to understand their rising appeal as potential biomarkers and therapeutic targets.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Coletto, Ms Lavinia
• Authors: Coletto, L. A., Rizzo, C., Guggino, G., Caporali, R., Alivernini, S., and Antonietta D’Agostino, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: International Journal of Molecular Sciences
• Publisher: MDPI
• ISSN: 1661-6596
• ISSN (Online): 1422-0067
• Copyright Holders: Copyright © 2023 by the Authors
• First Published: First published in International Journal of Molecular Sciences 24(4):4108
• Publisher Policy: Reproduced under a creative commons licence