The bio-exposome: intracellular processes, stress physiology and the environment

Minnis, H. et al. (2024) The bio-exposome: intracellular processes, stress physiology and the environment. Nature Mental Health, 2(2), pp. 132-140. (doi: 10.1038/s44220-023-00180-3)

Abstract

Most studies on the relationship between childhood adversity and negative outcomes across the lifespan have focused on individual exposures or outcomes—an approach that has been limited in its ability to elucidate mechanisms or causality. We propose a new framework for examining the relationship between childhood adversity and negative outcomes—the bio-exposome. In this model, we aim to understand the interconnections between every aspect of biology and the exposome, and the way disparate biological and exposome factors shape, and are shaped by, one another. Once we understand when, in which contexts and towards whom stress calibration interventions should be targeted, through examination of the bio-exposome, we could facilitate prevention of some of the major causes of morbidity across the lifespan. To examine the bio-exposome, we offer a new research agenda that embraces complexity science, large datasets and collaboration across a wide range of scientific disciplines.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Minnis, Professor Helen and Ho, Dr Frederick and Henderson, Prof Marion and Combet Aspray, Professor Emilie and Pell, Professor Jill and Rizeq, Dr Jala and Gillberg, Professor Christopher and Gajwani, Dr Ruchika and Shiels, Professor Paul
• Authors: Minnis, H., van Harmelen, A.-L., Gajwani, R., Rizeq, J., Combet, E., Reynolds, R. M., Gillberg, C., Henderson, M., Ho, F. K., Mondelli, V., Pell, J., Smith, J., and Shiels, P. G.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Nature Mental Health
• Publisher: Nature Research
• ISSN: 2731-6076
• ISSN (Online): 2731-6076
• Published Online: 09 February 2024
• Copyright Holders: Copyright © 2023 Springer Nature or its licensor
• First Published: First published in Nature Mental Health 2(2): 132-140
• Publisher Policy: Reproduced in accordance with the publisher copyright policy