Translation of a Diabetes Remission Service into Australian Primary Care: Findings from the Evaluation of DiRECT-Australia

Chimoriya, R., Mitlehner, K., Khoo, C. L., Osuagwu, U. L., Thomson, R., Si, L., Lean, M. , Simmons, D. and Piya, M. K. (2024) Translation of a Diabetes Remission Service into Australian Primary Care: Findings from the Evaluation of DiRECT-Australia. Journal of Diabetes Research, 2024, 2350551. (doi: 10.1155/2024/2350551) (PMID:38361965) (PMCID:PMC10869186)

Abstract

Background. The Diabetes Remission Clinical Trial (DiRECT) study demonstrated that an intensive and structured weight management program in UK primary care resulted in high rates of diabetes remission in adults with recent onset type 2 diabetes mellitus (T2DM). This study was aimed at evaluating the translation of the DiRECT intervention into an Australian primary care setting. Methods. All patients enrolled in the DiRECT-Australia Type 2 Diabetes Remission Service in a region of Sydney (Macarthur region, South Western Sydney, Australia) were included. Eligible participants were aged 20–70 years, noninsulin treated, with T2DM of ≤6 years’ duration, and body mass index BMI≥27 kg/m2. Total diet replacement of 825-853 kcal/day using meal replacements was implemented for 12 weeks, followed by an ongoing structured program until 52 weeks, with regular follow-up with a general practitioner, dietitian, and/or practice nurse. Results. Of 39 recruited participants, 32 (82.1%) and 27 (69.2%) completed 12 weeks and 52 weeks of the structured program, respectively. Decrease in weight by -12.0 kg (95% CI: -9.6, -14.4; p<0.001) and -9.1 kg (95% CI: -5.2, -12.9; p<0.001) and decrease in glycated haemoglobin (HbA1c) by -1.1% (95% CI: -0.6, -1.6; p<0.001) and -0.6% (95% CI: -0.1, -1.1; p=0.013) were observed at 12 and 52 weeks, respectively. At the end of 12 and 52 weeks, 93.8% (30/32) and 55.6% (15/27) of those with follow-up data met the criteria for diabetes remission, respectively. Quality of life and wellbeing scores increased over the course of 12 weeks, remaining significantly higher at 52 weeks. Participants reported they would be willing to pay A$92.50 (95% CI: A$75.80, A$109.30) per fortnight for the low-calorie meal replacement shakes. Conclusions. These findings support the feasibility of a structured diabetes remission service in an Australian primary care setting to achieve improvements in glycaemia, weight, and quality of life and wellbeing, and suggest a substantial willingness to pay for diet replacement products among participants.

• Item Type: Articles
• Additional Information: This study was funded by a charitable donation to Western Sydney University and the Ingham Institute by Tony and Ron Perich, as well as the Lady (Mary) Fairfax Trust. Author R.C. is in receipt of a Western Sydney University Postgraduate Research Scholarship, funded by the Ainsworth Trust, and has conducted this research as a part of his doctoral research. Open access publishing was facilitated by Western Sydney University, as part of the Wiley-Western Sydney University agreement via the Council of Australian University Librarians.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lean, Professor Michael
• Authors: Chimoriya, R., Mitlehner, K., Khoo, C. L., Osuagwu, U. L., Thomson, R., Si, L., Lean, M., Simmons, D., and Piya, M. K.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Diabetes Research
• Publisher: Hindawi
• ISSN: 2314-6745
• ISSN (Online): 2314-6753
• Copyright Holders: Copyright: © 2024 Ritesh Chimoriya et al.
• First Published: First published in Journal of Diabetes Research 2024: 2350551
• Publisher Policy: Reproduced under a Creative Commons licence