High inhibition for a CoII Tetrazole Bi‐pyrazole Dinuclear Complex against Fusarium Oxysporum f. sp. Albedinis

Bahjou, Y. et al. (2023) High inhibition for a CoII Tetrazole Bi‐pyrazole Dinuclear Complex against Fusarium Oxysporum f. sp. Albedinis. European Journal of Inorganic Chemistry, e202300634. (doi: 10.1002/ejic.202300634) (Early Online Publication)

Abstract

New coordination compounds made of two novel tetrazole and C,N-bipyrazole ligands, 2-(3,5,5′-trimethyl-1′H-[1,3′-bipyrazol]-1′-yl)acetonitrile (L1), and 1′-((1H-tetrazol-5-yl)methyl)-3,5,5′-trimethyl-1′H-1,3′-bipyrazole (HL2), were prepared and fully characterized by spectroscopic techniques. Their crystal structures were identified by single-crystal X-ray diffraction revealing mononuclear complexes: [Ni(L1)3](ClO4)2 (1), [Cd(L1)2Cl2] (2), [Cu(HL2)(L2)]ClO4 (3), [Cu(L2)2] (4) and a dinuclear complex [Co2(HL2)(L2)Cl3] (5) comprising CoII ions in octahedral and tetrahedral surrounding within the same unit. Noticeably, 3 and 4 show different architectural structures due to ligand deprotonation as well as the effect of the counter anion. All compounds demonstrated antimicrobial activity against Gram (+) bacteria Listeria innocua and Staphylococcus aureus, as well as Gram (−) bacteria such as Escherichia coli and Pseudomonas aeruginosa, and antifungal activity against pathogenic fungi Geotrichum candidum, Aspergillus niger, and Penicillium crustosum. Interestingly, a high inhibition activity of 97 % was reached for 5 with a low concentration of only 81.1 μmol/L against Fusarium oxysporum f. sp. Albedinis, which is commonly damaging palm trees crops.

• Item Type: Articles
• Additional Information: This research was supported by the Fonds de la Recherche Scientifique-FNRS (PDR T.0095.21, CDR J.0064.23, J.0168.22, EQP U.N027.24), PPR2-MESRSFC-CNRSTP10 project (Morocco), and University of Glasgow, and the COST action CA21149. We thank CNRST Morocco and WBI Morocco for an excellence PhD stipendium as well as the ARES for a PhD scholarship allocated to YB.
• Keywords: Tetrazole, C,N-bipyrazole, Cobalt, antimicrobial activity, bacteria, fusarium oxysporum f. sp. albedinis.
• Status: Early Online Publication
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Moiras, Professor Haralampos
• Authors: Bahjou, Y., Radi, S., El Massaoudi, M., Draoui, Y., Adarsh, N. N., Miras, H. N., Ferbinteanu, M., Robeyns, K., Ouahhoud, S., Benabbes, R., Hultzsch, K. C., Wolff, M., and Garcia, Y.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: European Journal of Inorganic Chemistry
• Publisher: Wiley
• ISSN: 1434-1948
• ISSN (Online): 1099-0682