Jackson, A. M. et al. (2024) A novel score to predict left ventricular recovery in peripartum cardiomyopathy derived from the ESC EORP Peripartum Cardiomyopathy Registry. European Heart Journal, (doi: 10.1093/eurheartj/ehad888) (PMID:38282532) (Early Online Publication)
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Abstract
Background and Aims There are no established clinical tools to predict left ventricular (LV) recovery in women with peripartum cardiomyopathy (PPCM). Using data from women enrolled in the ESC EORP PPCM Registry, the aim was to derive a prognostic model to predict LV recovery at 6 months and develop the ‘ESC EORP PPCM Recovery Score’—a tool for clinicians to estimate the probability of LV recovery. Methods From 2012 to 2018, 752 women from 51 countries were enrolled. Eligibility included (i) a peripartum state, (ii) signs or symptoms of heart failure, (iii) LV ejection fraction (LVEF) ≤ 45%, and (iv) exclusion of alternative causes of heart failure. The model was derived using data from participants in the Registry and internally validated using bootstrap methods. The outcome was LV recovery (LVEF ≥50%) at six months. An integer score was created. Results Overall, 465 women had a 6-month echocardiogram. LV recovery occurred in 216 (46.5%). The final model included baseline LVEF, baseline LV end diastolic diameter, human development index (a summary measure of a country’s social and economic development), duration of symptoms, QRS duration and pre-eclampsia. The model was well-calibrated and had good discriminatory ability (C-statistic 0.79, 95% confidence interval [CI] 0.74–0.83). The model was internally validated (optimism-corrected C-statistic 0.78, 95% CI 0.73–0.82). Conclusions A model which accurately predicts LV recovery at 6 months in women with PPCM was derived. The corresponding ESC EORP PPCM Recovery Score can be easily applied in clinical practice to predict the probability of LV recovery for an individual in order to guide tailored counselling and treatment.
| Item Type: | Articles |
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| Additional Information: | Since the start of EORP, the following companies have supported the whole research programme: Abbott Vascular Int. (2011–21), Amgen Cardiovascular (2009–18), AstraZeneca (2014–21), Bayer AG (2009– 18), Boehringer Ingelheim (2009–19), Boston Scientific (2009–12), The Bristol Myers Squibb and Pfizer Alliance (2011–19), Daiichi Sankyo Europe GmbH (2011–20), The Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company (2014–17), Edwards (2016–19), Gedeon Richter Plc. (2014–16), Menarini Int. Op. (2009– 12), MSD-Merck & Co. (2011–14), Novartis Pharma AG (2014–20), ResMed (2014–16), Sanofi (2009–11), SERVIER (2009–21), and Vifor (2019–22). A.M.J. was supported by a British Heart Foundation Clinical Research Training Fellowship (FS/18/14/33330), M.C.P. by a British Heart Foundation Centre of Excellence Research Grant (grant number 18/6/34217), P.v.d.M. by the European Research Council (ERC CoG 101045236, DISSECT-HF), and K.S. by Servier: Institut La Conference Hippocrate. |
| Keywords: | Cardiology and Cardiovascular Medicine |
| Status: | Early Online Publication |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Jackson, Dr Alice and Jhund, Professor Pardeep and Petrie, Professor Mark |
| Authors: | Jackson, A. M., Goland, S., Farhan, H. A., Yaseen, I. F., Prameswari, H. S., Böhm, M., Jhund, P. S., Maggioni, A. P., van der Meer, P., Sliwa, K., Bauersachs, J., and Petrie, M. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | European Heart Journal |
| Publisher: | Oxford University Press |
| ISSN: | 0195-668X |
| ISSN (Online): | 1522-9645 |
| Published Online: | 29 January 2024 |
| Copyright Holders: | Copyright: © The Author(s) 2024 |
| First Published: | First published in European Heart Journal 2024 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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