Effect of albiglutide on cardiovascular outcomes in older adults: a post hoc analysis of a randomized controlled trial

Gilbert, M. P., Skelly, J., Hernandez, A. F., Green, J. B., Krychtiuk, K. A., Granger, C. B., Leiter, L. A., McMurray, J. J.V. , Del Prato, S. and Pratley, R. E. (2024) Effect of albiglutide on cardiovascular outcomes in older adults: a post hoc analysis of a randomized controlled trial. Diabetes, Obesity and Metabolism, (doi: 10.1111/dom.15479) (PMID:38317618) (Early Online Publication)

Abstract

Aim: To analyse the effects of albiglutide, a glucagon‐like peptide 1 receptor agonist, on cardiovascular outcomes in older adults aged ≥65 years with type 2 diabetes and cardiovascular disease who participated in the Harmony Outcomes trial (NCT02465515). Materials and methods: We conducted a post hoc analysis of the primary endpoint of the Harmony Outcomes trial—time to first occurrence of a major adverse cardiovascular event—in subgroups of participants aged <65 and ≥65 years and <75 and ≥75 years at baseline. Hazard ratios and 95% confidence intervals (CIs) were generated using Cox proportional hazards regression. Results: The analysis population included 9462 Harmony Outcomes participants, including 4748 patients ≥65 and 1140 patients ≥75 years at baseline. Hazard ratios for the prevention of major adverse cardiovascular events were 0.66 (95% CI, 0.53‐0.82) in persons <65 and 0.86 (95% CI, 0.71‐1.04) in those ≥65 years (age interaction p = .07), and 0.78 (95% CI, 0.67‐0.91) in <75 and 0.70 (95% CI, 0.48‐1.01) in ≥75 year age groups (interaction p = .6). When analysed as a continuous variable, age did not modify the effect of albiglutide on the primary endpoint. Conclusions: This post hoc analysis adds to the body of literature showing that glucagon‐like peptide 1 receptor agonists added to standard type 2 diabetes therapy safely reduce the incidence of cardiovascular events in older adults with established cardiovascular disease. In this analysis, the risk‐benefit profile was similar between younger and older age groups treated with albiglutide.

• Item Type: Articles
• Status: Early Online Publication
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMurray, Professor John
• Authors: Gilbert, M. P., Skelly, J., Hernandez, A. F., Green, J. B., Krychtiuk, K. A., Granger, C. B., Leiter, L. A., McMurray, J. J.V., Del Prato, S., and Pratley, R. E.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Diabetes, Obesity and Metabolism
• Publisher: Wiley
• ISSN: 1462-8902
• ISSN (Online): 1463-1326
• Copyright Holders: Copyright © 2024 The Authors
• First Published: First published in Diabetes, Obesity and Metabolism 2024
• Publisher Policy: Reproduced under a Creative Commons licence