Exploring and disentangling the production of potentially bioactive phenolic catabolites from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines

Clifford, M. N. et al. (2024) Exploring and disentangling the production of potentially bioactive phenolic catabolites from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines. Redox Biology, 71, 103068. (doi: 10.1016/j.redox.2024.103068) (PMID:38377790) (PMCID:PMC10891336)

Abstract

Following ingestion of fruits, vegetables and derived products, (poly)phenols that are not absorbed in the upper gastrointestinal tract pass to the colon, where they undergo microbiota-mediated ring fission resulting in the production of a diversity of low molecular weight phenolic catabolites, which appear in the circulatory system and are excreted in urine along with their phase II metabolites. There is increasing interest in these catabolites because of their potential bioactivity and their use as biomarkers of (poly)phenol intake. Investigating the fate of dietary (poly)phenolics in the colon has become confounded as a result of the recent realisation that many of the phenolics appearing in biofluids can also be derived from the aromatic amino acids, l-phenylalanine and l-tyrosine, and to a lesser extent catecholamines, in reactions that can be catalysed by both colonic microbiota and endogenous mammalian enzymes. The available evidence, albeit currently rather limited, indicates that substantial amounts of phenolic catabolites originate from phenylalanine and tyrosine, while somewhat smaller quantities are produced from dietary (poly)phenols. This review outlines information on this topic and assesses procedures that can be used to help distinguish between phenolics originating from dietary (poly)phenols, the two aromatic amino acids and catecholamines.

• Item Type: Articles
• Additional Information: A.C., G.P.-C., G.I.R.G, and T.M.A. were funded by the Distinguished Scientist Fellowship Program (DSFP) of King Saud University, Riyadh, Saudi Arabia. I.A.L. was supported by the Gobierno de Navarra: Grant no. 0011-3947-2021-000034. P.M. received funding from the European Union’s Horizon 2020 Research and Innovation Programme: Grant no. 950050; and the National Recovery and Resilience Plan of the Italian Ministry of University and Research and the European Union: Project code PE00000003.
• Keywords: Bioactive phenolic catabolites, dietary (poly)phenolics, microbiota-mediated catabolism, endogenous metabolism, aromatic amino acids, catecholamines.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Crozier, Professor Alan and Borges, Dr Gina and Ludwig, Ms Iziar

Creator Roles

Ludwig, I.: Writing – review and editing
Borges, G.: Conceptualization, Writing – review and editing
Crozier, A.: Conceptualization, Writing – original draft, Writing – review and editing

• Authors: Clifford, M. N., Ludwig, I. A., Pereira-Caro, G., Zeraik, L., Borges, G., Almutairi, T. M., Dobani, S., Bresciani, L., Mena, P., Gill, C. I.R., and Crozier, A.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Redox Biology
• Publisher: Elsevier
• ISSN: 2213-2317
• ISSN (Online): 2213-2317
• Published Online: 19 February 2024
• Copyright Holders: Copyright: © 2024 The Authors
• First Published: First published in Redox Biology 71: 103068
• Publisher Policy: Reproduced under a Creative Commons licence