Nakada, S. , Ho, F. K., Celis-Morales, C. and Pell, J. P. (2024) Schizophrenia and types of stroke: A Mendelian randomization study. Journal of the American Heart Association, 13(5), e032011. (doi: 10.1161/JAHA.123.032011) (PMID:38420769) (PMCID:PMC10944050)
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Abstract
Background: Previous studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and hemorrhagic stroke outcomes. Methods and Results: Two‐sample Mendelian randomization analyses were conducted. The summary‐level data (restricted to European ancestry) were obtained for schizophrenia and stroke: ischemic stroke, large‐artery stroke, small‐vessel stroke, cardioembolic stroke, and intracerebral hemorrhage. The associations between schizophrenia and each outcome were analyzed by an inverse variance weighting method primarily and Mendelian randomization Egger, weighted median, and weighted mode subsequently. The presence of pleiotropy was also tested by Cochran Q statistic, I2 index, and Mendelian randomization Egger intercept with scatter and funnel plots. We found associations between schizophrenia and cardioembolic stroke (odds ratio [OR], 1.070 [95% CI, 1.023–1.119]) and intracerebral hemorrhage (OR, 1.089 [95% CI, 1.005–1.180]) using inverse variance weighting. Little evidence of associations with the other stroke subtypes was found. Different Mendelian randomization methods corroborated the association with cardioembolic stroke but not intracerebral hemorrhage. Conclusions: We have provided evidence of a potentially causal association between schizophrenia and cardioembolic stroke. Our findings suggest that cardiac evaluation should be considered for those with schizophrenia.
| Item Type: | Articles |
|---|---|
| Additional Information: | The MEGASTROKE project received funding from sources specified at https://www.megastroke.org/acknowledgements.html. We are also grateful to the Medical Research Council and the University of Edinburgh/University of Glasgow. This work was supported by the Medical Research Council (MR/N013166/1- LGH/MS/MED2525). SN is supported by a PhD studentship award from the Medical Research Council (MR/N013166/1-LGH/MS/MED2525). |
| Keywords: | schizophrenia, stroke, ischemic, hemorrhagic, Mendelian randomization. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Pell, Professor Jill and Celis, Dr Carlos and Ho, Dr Frederick and Nakada, Shinya |
| Authors: | Nakada, S., Ho, F. K., Celis-Morales, C., and Pell, J. P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
| Journal Name: | Journal of the American Heart Association |
| Publisher: | American Heart Association |
| ISSN: | 2047-9980 |
| ISSN (Online): | 2047-9980 |
| Published Online: | 29 February 2024 |
| Copyright Holders: | Copyright © 2024 The Author(s) |
| First Published: | First published in Journal of the American Heart Association 13(5):e032011 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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