Alghanimy, A., Work, L. M. and Holmes, W. M. (2024) The glymphatic system and multiple sclerosis: An evolving connection. Multiple Sclerosis and Related Disorders, 83, 105456. (doi: 10.1016/j.msard.2024.105456)
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Abstract
Multiple sclerosis (MS) is a complex autoimmune disorder that affects the central nervous system, resulting in demyelination and an array of neurological manifestations. Recently, there has been significant scientific interest in the glymphatic system, which operates as a waste-clearance system for the brain. This article reviews the existing literature, and explores potential links between the glymphatic system and MS, shedding light on its evolving significance in the context of MS pathogenesis. The authors consider the pathophysiological implications of glymphatic dysfunction in MS, the impact of disrupted sleep on glymphatic function, and the bidirectional relationship between MS and sleep disturbances. By offering an understanding of the intricate interplay between the glymphatic system and MS, this review provides valuable insights which may lead to improved diagnostic techniques and more effective therapeutic interventions.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Work, Dr Lorraine and alghanimy, Alaa and Holmes, Dr William |
| Creator Roles: | Alghanimy, A.Investigation alghanimy, A.Methodology, Writing – original draft, Writing – review and editing Work, L.Supervision, Writing – review and editing Holmes, W.Supervision, Writing – review and editing |
| Authors: | Alghanimy, A., Work, L. M., and Holmes, W. M. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | Multiple Sclerosis and Related Disorders |
| Publisher: | Elsevier |
| ISSN: | 2211-0348 |
| ISSN (Online): | 2211-0356 |
| Published Online: | 21 January 2024 |
| Copyright Holders: | Copyright: © 2024 The Author(s) |
| First Published: | First published in Multiple Sclerosis and Related Disorders 83: 105456 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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