Current understandings of colibactin regulation

Addington, E., Sandalli, S. and Roe, A. J. (2024) Current understandings of colibactin regulation. Microbiology, 170(2), 001427. (doi: 10.1099/mic.0.001427) (PMID:38314762)

Abstract

The biosynthetic machinery for the production of colibactin is encoded by 19 genes (clbA – S) within the pks pathogenicity island harboured by many E. coli of the B2-phylogroup. Colibactin is a potent genotoxic metabolite which causes DNA-damage and which has potential roles in microbial competition and fitness of pks+ bacteria. Colibactin has also been strongly implicated in the development of colorectal cancer. Given the genotoxicity of colibactin and the metabolic cost of its synthesis, the regulatory system governing the clb cluster is accordingly highly complex, and many of the mechanisms remain to be elucidated. In this review we summarise the current understanding of regulation of colibactin biosynthesis by internal molecular components and how these factors are modulated by signals from the external environment.

• Item Type: Articles
• Additional Information: S.S. supported by the Wellcome Trust Integrative Infection Biology PhD Programme at the University of Glasgow, grant number 218518/Z/19/Z. A.J.R. and E.A. are supported by the Biotechnology and Biological Sciences Research Council [BB/W015781/1].
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Roe, Professor Andrew and Sandalli, Sofia and Addington, Dr Emily
• Authors: Addington, E., Sandalli, S., and Roe, A. J.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Microbiology
• Publisher: Microbiology Society
• ISSN: 1350-0872
• ISSN (Online): 1465-2080
• Copyright Holders: Copyright © 2024 The Authors
• First Published: First published in Microbiology 170(2):001427
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
316367		D-amino acids as modulatros of the genotoxic polyketide colibactin	Andrew Roe	Biotechnology and Biological Sciences Research Council (BBSRC)	BB/W015781/1	SII - Bacteriology
309785		Integrative Infection Biology - Mechanisms and Control of Disease	Megan MacLeod	Wellcome Trust (WELLCOTR)	218518/Z/19/Z	SBOHVM - Host-Parasite Interactions & Pathogenesis