Guan, D., Wang, Y., Luo, X. , Danton, M. and Gao, H. (2023) A Modelling Study of Pulmonary Regurgitation in a Personalized Human Heart. In: 12th International Conference on Functional Imaging and Modeling of the Heart, Lyon, France, 19-22 Jun 2023, ISBN 9783031353017 (doi: 10.1007/978-3-031-35302-4_60)
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Abstract
Pulmonary regurgitation is a frequent outcome of repaired tetralogy of Fallot, and its chronicity could have a detrimental effect on right ventricle function. To evaluate the effects of PR on cardiac functions, a subject-specific bi-ventricular model is developed in this study coupled with a closed-loop parameter model to depict systemic and pulmonary circulations. After calibrating the normal bi-ventricle model with in vivo measurement, pulmonary regurgitation is introduced by a one-directional channel connecting the right ventricle and pulmonary artery. We have demonstrated that this developed bi-ventricular model can reproduce the main characteristics of cardiac functions under pulmonary regurgitation, such as increased end-diastolic pressure and volume, diminishment of isovolumetric relaxation, enhanced active tension in the right ventricle, and the bulged septum towards the left ventricle. Once validated, it is believed this cardiac model will be very useful to provide insights into cardiac biomechanical function under pulmonary regurgitation.
| Item Type: | Conference Proceedings |
|---|---|
| Additional Information: | eISBN - 9783031353024. Funding: We are grateful for the funding provided by the British Heart Foundation (ref: PG/22/10930), and the UK Engineering and Physical Sciences Research Council (EP/S030875, EP/S020950/1, EP/S014284/1, EP/R511705/1). |
| Keywords: | Pulmonary regurgitation; Bi-ventricular model; Closed-loop circulation model; Cardiac function |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gao, Dr Hao and Luo, Professor Xiaoyu and Guan, Mr Debao and Danton, Professor Mark and Wang, Yingjie |
| Authors: | Guan, D., Wang, Y., Luo, X., Danton, M., and Gao, H. |
| Subjects: | Q Science > QA Mathematics |
| College/School: | College of Science and Engineering > School of Mathematics and Statistics > Mathematics |
| Publisher: | Springer, Cham |
| ISSN: | 0302-9743 |
| ISBN: | 9783031353017 |
| Copyright Holders: | Copyright: © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023, corrected publication 2023 |
| First Published: | First published in Functional Imaging and Modeling of the Heart: 12th International Conference, FIMH 2023: Lyon, France, June 19-22, 2023 Proceedings |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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