Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis

Caiazzo, E. et al. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, (doi: 10.1016/j.phrs.2023.107050) (PMID:38159784) (In Press)

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Abstract

Background: Immune responses play a significant role in hypertension, though the importance of key inflammatory mediators remains to be defined. We used a systematic literature review and meta-analysis to study the associations between key cytokines and incident hypertension. Methods: We performed a systematic search of Pubmed/Medline, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL), for peer-reviewed studies published up to August 2022. Incident hypertension was defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg and/or the use of antihypertensive medications. Random effects meta-analyses were used to calculate pooled hazard ratios (HRs)/risk ratios (RRs) and 95% confidence intervals by cytokine levels (highest vs. lowest quartile). Results: Only IL-6 and IL-1β levels have evidence allowing for quantitative evaluation concerning the onset of hypertension. Six studies (10,406 participants, 2,932 incident cases) examined the association of IL-6 with incident hypertension. The highest versus lowest quartile of circulating IL-6 was associated with a significant HR/RR of hypertension (1.61, 95% CI: 1.00 to 2.60; I2=87%). After adjusting for potential confounders, including body mass index (BMI), HR/RR was no longer significant (HR/RR: 1.24; 95% CI, 0.96 to 1.61; I2= 56%). About IL-1β, neither the crude (HR/RR: 1.03; 95% CI, 0.60 to 1.76; n=2) nor multivariate analysis (HR/RR: 0.97, 95% CI, 0.60 to 1.56; n=2) suggested a significant association with the risk of developing hypertension. Conclusions: A limited number of studies suggest that higher IL-6, but not IL-1β, might be associated with the development of hypertension.

Item Type:Articles
Additional Information:TJG is supported by the European Research Council (ERC and InflammaTENSION, ERC-CoG-726318); European Research Area - CVD (ERA-CVD) (BrainGutImmune (ERA-CVD/Gut-brain/8/2021 and ImmmuneHyperCog, NCBiR Poland), British Heart Foundation grants (FS/14/49/30838 and FS/4yPhD/F/20/34127 A) and as part of the British Heart Foundation Centre for Research Excellence at the University of Edinburgh (RE/18/5/34216). PM is supported by British Heart Foundation grants (PG/19/84/34771, FS/19/56/34893 A, PG/21/10541, PG/21/10557 and PG/21/10634), the Erasmus+ International Credit Mobility (ICM) (grant 2020-1-UK01-KA107-078782); and FRA 2020 - Linea A, University of Naples Federico II/Compagnia di San Paolo. AI is supported by the Italian Ministry of University and Research (MIUR) PRIN 2017 (2017NKB2N4_003) and PRIN 2020 (20203YAY9B).
Status:In Press
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maffia, Professor Pasquale and Rezig, Asma Oumkaltoum and Czesnikiewicz-Guzik, Dr Marta and Guzik, Professor Tomasz and CAIAZZO, Miss ELISABETTA and Sulicka Grodzicka, Dr Joanna and SHARMA, MALVIKA and Pellicori, Dr Pierpaolo
Creator Roles:
Caiazzo, E.Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review and editing
Sharma, M.Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review and editing
Rezig, A. O.M.Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review and editing
Czesnikiewicz-Guzik, M.Writing – review and editing
Sulicka Grodzicka, J.Writing – review and editing
Pellicori, P.Data curation, Supervision, Writing – review and editing
Maffia, P.Conceptualization, Funding acquisition, Supervision, Writing – review and editing
Guzik, T. J.Conceptualization, Funding acquisition, Supervision, Writing – review and editing
Authors: Caiazzo, E., Sharma, M., Rezig, A. O.M., Morsay, M. I., Czesnikiewicz-Guzik, M., Ialenti, A., Sulicka-Grodzicka, J., Pellicori, P., Crouch, S. H., Schutte, A. E., Bruzzese, D., Maffia, P., and Guzik, T. J.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Pharmacological Research
Publisher:Elsevier
ISSN:1043-6618
ISSN (Online):1096-1186
Published Online:29 December 2023
Copyright Holders:Copyright © The Author(s) 2023
First Published:First published in Pharmacological Research 2023
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
300798A study of the roles of the immune and inflammatory systems in hypertensionTomasz GuzikEuropean Research Council (ERC)726318SCMH - Cardiovascular & Metabolic Health
308639Defining the individual and integrated roles of inflammatory chemokine receptors (iCCRs) in atherosclerosisPasquale MaffiaBritish Heart Foundation (BHF)PG/19/84/34771SCMH - Cardiovascular & Metabolic Health
170444Assessing the contribution of microRNA to in-stent restenosisTomasz GuzikBritish Heart Foundation (BHF)FS/14/49/30838School of Cardiovascular & Metabolic Health
311102BHF 4Yr PhD Studentship Award 2020Rhian TouyzBritish Heart Foundation (BHF)FS/4yPhD/F/20/34127SCMH - Cardiovascular & Metabolic Health
308639Defining the individual and integrated roles of inflammatory chemokine receptors (iCCRs) in atherosclerosisPasquale MaffiaBritish Heart Foundation (BHF)PG/19/84/34771SCMH - Cardiovascular & Metabolic Health
309321BHF 4Yr PhD Studentship Award 2109Rhian TouyzBritish Heart Foundation (BHF)FS/19/56/34893SCMH - Cardiovascular & Metabolic Health
313479Defining AXL Role in AtherosclerosisPasquale MaffiaBritish Heart Foundation (BHF)PG/21/10541SCMH - Cardiovascular & Metabolic Health
314413Defining the IL-21/IL-21 receptor axis role(s) in atherosclerosisPasquale MaffiaBritish Heart Foundation (BHF)PG/21/10634SCMH - Cardiovascular & Metabolic Health