Cell competition and cancer from Drosophila to mammals

Cong, B. and Cagan, R. L. (2024) Cell competition and cancer from Drosophila to mammals. Oncogenesis, 13(1), 1. (doi: 10.1038/s41389-023-00505-y) (PMID:38172609) (PMCID:PMC10764339)

Abstract

Throughout an individual’s life, somatic cells acquire cancer-associated mutations. A fraction of these mutations trigger tumour formation, a phenomenon partly driven by the interplay of mutant and wild-type cell clones competing for dominance; conversely, other mutations function against tumour initiation. This mechanism of ‘cell competition’, can shift clone dynamics by evaluating the relative status of clonal populations, promoting ‘winners’ and eliminating ‘losers’. This review examines the role of cell competition in the context of tumorigenesis, tumour progression and therapeutic intervention.

• Item Type: Articles
• Additional Information: The research conducted in the Cagan laboratory received generous support from multiple sources, including grants from the NIH (R01CA258736), the Pershing Square Sohn Foundation, and the Baillie Gifford Foundation, as well as a Royal Society Wolfson Fellowship.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cagan, Professor Ross and Cong, Mr Bojie
• Authors: Cong, B., and Cagan, R. L.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Oncogenesis
• Publisher: Springer Nature
• ISSN: 2157-9024
• ISSN (Online): 2157-9024
• Copyright Holders: Copyright © 2024 The Authors
• First Published: First published in Oncogenesis 13(1):1
• Publisher Policy: Reproduced under a Creative Commons License