Hyperprogesteronism associated with adrenocortical tumours in two dogs

Farges, A., Crawford, D., Adrega da Silva, C. and Ramsey, I. (2024) Hyperprogesteronism associated with adrenocortical tumours in two dogs. Veterinary Record Case Reports, (doi: 10.1002/vrc2.794) (Early Online Publication)

Abstract

A 9-year-old, entire, female, soft-coated Wheaten terrier and a 7-year-old, male, neutered greyhound were presented for clinical signs suggestive of hyperadrenocorticism (polyuria, polydipsia, and in the first case, polyphagia and weight gain). Adrenocorticotrophic hormone stimulation test and low-dose dexamethasone suppression test ruled out excessive production of cortisol. Imaging (abdominal ultrasound and computed tomography) revealed an adrenal mass in both cases. Further hormonal testing revealed hyperprogesteronism. In the first case, surgical treatment was not considered due to vascular invasion of the mass, the patient was treated successfully with trilostane and was still stable 18 months later. In the second case, adrenalectomy was performed, and the clinical signs resolved, the dog was stable 10 months later. We report two clinical cases of progesterone-secreting adrenocortical tumours and their management.

• Item Type: Articles
• Status: Early Online Publication
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ramsey, Professor Ian and Farges, Anais
• Authors: Farges, A., Crawford, D., Adrega da Silva, C., and Ramsey, I.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Veterinary Record Case Reports
• Publisher: Wiley
• ISSN: 2052-6121
• ISSN (Online): 2052-6121
• Published Online: 04 January 2024
• Copyright Holders: Copyright: © 2024 The Authors
• First Published: First published in Veterinary Record Case Reports 2024
• Publisher Policy: Reproduced under a Creative Commons licence